Qu Tian1, Rebecca Ehrenkranz2, Andrea L Rosso2, Nancy W Glynn2, Lana M Chahine3, James Hengenius2, Xiaonan Zhu2, Caterina Rosano2. 1. Translational Gerontology Branch Longitudinal Studies Section, National Institute on Aging, Baltimore, Maryland, USA. 2. Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania, USA. 3. Department of Neurology, School of Medicine, University of Pittsburgh, Pennsylvania, USA.
Abstract
BACKGROUND: Mild parkinsonian signs (MPS), highly prevalent in older adults, predict disability. It is unknown whether energy decline, a predictor of mobility disability, is also associated with MPS. We hypothesized that those with MPS had greater decline in self-reported energy level (SEL) than those without MPS, and that SEL decline and MPS share neural substrates. METHOD: Using data from the Health, Aging and Body Composition Study, we analyzed 293 Parkinson's disease-free participants (83 ± 3 years old, 39% Black, 58% women) with neuroimaging data, MPS evaluation by Unified Parkinson Disease Rating Scale in 2006-2008, and ≥3 measures of SEL since 1999-2000. Individual SEL slopes were computed via linear mixed models. Associations of SEL slopes with MPS were tested using logistic regression models. Associations of SEL slope with volume of striatum, sensorimotor, and cognitive regions were examined using linear regression models adjusted for normalized total gray matter volume. Models were adjusted for baseline SEL, mobility, demographics, and comorbidities. RESULTS: Compared to those without MPS (n = 165), those with MPS (n = 128) had 37% greater SEL decline in the prior 8 years (p = .001). Greater SEL decline was associated with smaller right striatal volume (adjusted standardized β = 0.126, p = .029). SEL decline was not associated with volumes in other regions. The association of SEL decline with MPS remained similar after adjustment for right striatal volume (adjusted odds ratio = 2.03, 95% CI: 1.16-3.54). CONCLUSION: SEL decline may be faster in those with MPS. Striatal atrophy may be important for declining energy but does not explain the association with MPS.
BACKGROUND: Mild parkinsonian signs (MPS), highly prevalent in older adults, predict disability. It is unknown whether energy decline, a predictor of mobility disability, is also associated with MPS. We hypothesized that those with MPS had greater decline in self-reported energy level (SEL) than those without MPS, and that SEL decline and MPS share neural substrates. METHOD: Using data from the Health, Aging and Body Composition Study, we analyzed 293 Parkinson's disease-free participants (83 ± 3 years old, 39% Black, 58% women) with neuroimaging data, MPS evaluation by Unified Parkinson Disease Rating Scale in 2006-2008, and ≥3 measures of SEL since 1999-2000. Individual SEL slopes were computed via linear mixed models. Associations of SEL slopes with MPS were tested using logistic regression models. Associations of SEL slope with volume of striatum, sensorimotor, and cognitive regions were examined using linear regression models adjusted for normalized total gray matter volume. Models were adjusted for baseline SEL, mobility, demographics, and comorbidities. RESULTS: Compared to those without MPS (n = 165), those with MPS (n = 128) had 37% greater SEL decline in the prior 8 years (p = .001). Greater SEL decline was associated with smaller right striatal volume (adjusted standardized β = 0.126, p = .029). SEL decline was not associated with volumes in other regions. The association of SEL decline with MPS remained similar after adjustment for right striatal volume (adjusted odds ratio = 2.03, 95% CI: 1.16-3.54). CONCLUSION: SEL decline may be faster in those with MPS. Striatal atrophy may be important for declining energy but does not explain the association with MPS.
Authors: Caterina Rosano; David A Bennett; Anne B Newman; Vijay Venkatraman; Kristine Yaffe; Tamara Harris; Stephen Kritchevsky; Howard J Aizenstein Journal: J Gerontol A Biol Sci Med Sci Date: 2012-02-24 Impact factor: 6.053
Authors: Emily Wasson; Andrea L Rosso; Adam J Santanasto; Caterina Rosano; Meryl A Butters; W Jack Rejeski; Robert M Boudreau; Howard Aizenstein; Theresa Gmelin; Nancy W Glynn Journal: Exp Gerontol Date: 2018-12-04 Impact factor: 4.032
Authors: Qu Tian; Nancy W Glynn; Rebecca C Ehrenkranz; Briana N Sprague; Andrea L Rosso; Caterina Rosano Journal: J Am Geriatr Soc Date: 2020-06-08 Impact factor: 7.538