BACKGROUND: Immunocompromised patients were excluded from the trials of SARS-CoV-2 vaccines. Boyarsky et al recently reported that, only 17% of transplant recipients who received a single dose of SARS-CoV-2 vaccine developed detectable anti-spike antibody (compared to 100% of the nonimmunocompromised subjects in the pivotal trials) and after 2 doses response increased to 54% in transplant recipients.1,2. METHODS: Retrospective chart review of 14 patients who were diagnosed with COVID-19 despite completion of vaccination series. RESULTS: Fourteen SOT recipients were diagnosed with COVID-19 a median of 23.5 days from completion of vaccination. One patient died, 2 remain hospitalized and 11 are recovered at home. Fifty percent of patients infected required hospitalization for treatment of disease. CONCLUSIONS: With this report of 14 patients who developed COVID-19 infection after completion of vaccination, we believe there is sufficient evidence to issue warnings that immunoincompetent populations should continue to practice strict COVID-19 precautions postvaccination. Transplant centers should reinforce that guidance given to the general population may not be applicable to the transplant population. A centralized transplant registry of fully vaccinated solid organ transplant patients who develop COVID-19 infections is vital. Further studies are critically needed to optimize COVID-19 vaccination protocols in transplant recipients.
BACKGROUND: Immunocompromised patients were excluded from the trials of SARS-CoV-2 vaccines. Boyarsky et al recently reported that, only 17% of transplant recipients who received a single dose of SARS-CoV-2 vaccine developed detectable anti-spike antibody (compared to 100% of the nonimmunocompromised subjects in the pivotal trials) and after 2 doses response increased to 54% in transplant recipients.1,2. METHODS: Retrospective chart review of 14 patients who were diagnosed with COVID-19 despite completion of vaccination series. RESULTS: Fourteen SOT recipients were diagnosed with COVID-19 a median of 23.5 days from completion of vaccination. One patient died, 2 remain hospitalized and 11 are recovered at home. Fifty percent of patientsinfected required hospitalization for treatment of disease. CONCLUSIONS: With this report of 14 patients who developed COVID-19infection after completion of vaccination, we believe there is sufficient evidence to issue warnings that immunoincompetent populations should continue to practice strict COVID-19 precautions postvaccination. Transplant centers should reinforce that guidance given to the general population may not be applicable to the transplant population. A centralized transplant registry of fully vaccinated solid organ transplant patients who develop COVID-19infections is vital. Further studies are critically needed to optimize COVID-19 vaccination protocols in transplant recipients.
Authors: Meryl Waldman; Maria Jose Soler; Clara García-Carro; Liz Lightstone; Tabitha Turner-Stokes; Megan Griffith; Joan Torras; Laura Martinez Valenzuela; Oriol Bestard; Colin Geddes; Oliver Flossmann; Kelly L Budge; Chiara Cantarelli; Enrico Fiaccadori; Marco Delsante; Enrique Morales; Eduardo Gutierrez; Jose A Niño-Cruz; Armando J Martinez-Rueda; Giorgia Comai; Claudia Bini; Gaetano La Manna; Maria F Slon; Joaquin Manrique; Alejandro Avello; Raul Fernandez-Prado; Alberto Ortiz; Smaragdi Marinaki; Carmen Rita Martin Varas; Cristina Rabasco Ruiz; Milagros Sierra-Carpio; Rebeca García-Agudo; Gema Fernández Juárez; Alexander J Hamilton; Annette Bruchfeld; Constantina Chrysochou; Lilian Howard; Smeeta Sinha; Tim Leach; Irene Agraz Pamplona; Umberto Maggiore; Paolo Cravedi Journal: Kidney360 Date: 2021-12-03
Authors: Mario Fernández-Ruiz; Patricia Almendro-Vázquez; Octavio Carretero; Tamara Ruiz-Merlo; Rocío Laguna-Goya; Rafael San Juan; Francisco López-Medrano; Estéfani García-Ríos; Vicente Más; Miguel Moreno-Batenero; Carmelo Loinaz; Amado Andrés; Pilar Pérez-Romero; Estela Paz-Artal; José María Aguado Journal: Transplant Direct Date: 2021-11-17
Authors: Chris J Callaghan; Lisa Mumford; Rebecca M K Curtis; Sarah V Williams; Heather Whitaker; Nick Andrews; Jamie Lopez Bernal; Ines Ushiro-Lumb; Gavin J Pettigrew; Douglas Thorburn; John L R Forsythe; Rommel Ravanan Journal: Transplantation Date: 2022-03-01 Impact factor: 4.939
Authors: Edward J Carr; Andreas Kronbichler; Matthew Graham-Brown; Graham Abra; Christos Argyropoulos; Lorraine Harper; Edgar V Lerma; Rita S Suri; Joel Topf; Michelle Willicombe; Swapnil Hiremath Journal: Kidney Int Rep Date: 2021-07-06