Mohammad Tasavon Gholamhoseini1, Vahid Yazdi-Feyzabadi2, Reza Goudarzi1, Mohammad Hossein Mehrolhassani3. 1. Health Services Management Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran. 2. Health in Disasters and Emergencies Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran. 3. Social Determinants of Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran.
Abstract
PURPOSE: To evaluate the safety and efficacy of remdesivir in adult patients with COVID-19. METHODS: PubMed, Embase, Scopus, Web of Science, Cochrane Library, ClinicalTrials.gov, and medRxiv databases were searched using a search strategy tailored to each database. The Consolidated Standards of Reporting Trials (CONSORT) and Strengthening the reporting of observational studies in epidemiology (STROBE) checklists were used for the studies' qualitative assessment. The outcomes studied were mortality, all adverse events, serious adverse events, and clinical improvement. The quantitative synthesis was conducted using fixed and random effects models in the CMA 2.2. Heterogeneity was tested using the I-squared (I2) measure. RESULTS: In general, six studies, including five randomized controlled trials and one cohort study were found eligible. Comparison of the findings related to both groups receiving remdesivir (10-day remdesivir group) and placebo/control group showed that remdesivir treatment had no significant effect on mortality at day 14 of the treatment (RR=0.769; 95% CI :0.563-1.050; p=0.098), and all adverse events (RR= 1.078; 95% CI: 0.908-1.279; p= 0.392). However, remdesivir had a significant effect on clinical improvement at day 14 compared to placebo/control (OR= 1.447; 95% CI: 1.005-2.085; p= 0.047) and reduced serious adverse events (RR= 0.736; 95% CI: 0.611-0.887; p= 0.001). CONCLUSION: Remdesivir has positive effects on clinical improvement, and reduction of the risk of serious adverse events. However, it does not influence the mortality at day 14 of treatment.
PURPOSE: To evaluate the safety and efficacy of remdesivir in adult patients with COVID-19. METHODS: PubMed, Embase, Scopus, Web of Science, Cochrane Library, ClinicalTrials.gov, and medRxiv databases were searched using a search strategy tailored to each database. The Consolidated Standards of Reporting Trials (CONSORT) and Strengthening the reporting of observational studies in epidemiology (STROBE) checklists were used for the studies' qualitative assessment. The outcomes studied were mortality, all adverse events, serious adverse events, and clinical improvement. The quantitative synthesis was conducted using fixed and random effects models in the CMA 2.2. Heterogeneity was tested using the I-squared (I2) measure. RESULTS: In general, six studies, including five randomized controlled trials and one cohort study were found eligible. Comparison of the findings related to both groups receiving remdesivir (10-day remdesivir group) and placebo/control group showed that remdesivir treatment had no significant effect on mortality at day 14 of the treatment (RR=0.769; 95% CI :0.563-1.050; p=0.098), and all adverse events (RR= 1.078; 95% CI: 0.908-1.279; p= 0.392). However, remdesivir had a significant effect on clinical improvement at day 14 compared to placebo/control (OR= 1.447; 95% CI: 1.005-2.085; p= 0.047) and reduced serious adverse events (RR= 0.736; 95% CI: 0.611-0.887; p= 0.001). CONCLUSION:Remdesivir has positive effects on clinical improvement, and reduction of the risk of serious adverse events. However, it does not influence the mortality at day 14 of treatment.
Authors: Ahmad Al Bishawi; Hamad Abdel Hadi; Eman Elmekaty; Musaed Al Samawi; Arun Nair; Mohammed Abou Kamar; Muna Al Maslamani; Alaaeldin Abdelmajid Journal: Clin Case Rep Date: 2022-02-24
Authors: Jerzy Jaroszewicz; Justyna Kowalska; Małgorzata Pawłowska; Magdalena Rogalska; Dorota Zarębska-Michaluk; Marta Rorat; Beata Lorenc; Piotr Czupryna; Katarzyna Sikorska; Anna Piekarska; Anna Dworzańska; Izabela Zaleska; Włodzimierz Mazur; Dorota Kozielewicz; Krzysztof Kłos; Regina Podlasin; Grzegorz Angielski; Barbara Oczko-Grzesik; Magdalena Figlerowicz; Bartosz Szetela; Beata Bolewska; Paulina Frańczak-Chmura; Robert Flisiak; Krzysztof Tomasiewicz Journal: Cancers (Basel) Date: 2022-09-28 Impact factor: 6.575