| Literature DB >> 34048010 |
Belgacem Mihi1, Wyatt E Lanik1, Qingqing Gong1, Misty Good2.
Abstract
Necrotizing enterocolitis (NEC) is an acute inflammatory disease that unforeseeably develops in very low birth weight premature infants. NEC is characterized by impairment of the intestinal barrier resulting in intestinal necrosis and multisystem organ failure. Animal models of NEC have contributed significantly to a better understanding of the underlying molecular mechanisms of the disease and facilitated the exploration of potential new therapeutic strategies. Here, we provide a detailed protocol that recapitulates some of the main histological and transcriptional features of human NEC in newborn mice.Entities:
Keywords: Enteric bacteria; Intestinal inflammation; Mucosal barrier; Necrotizing enterocolitis; Neonatal mice
Mesh：
Year: 2021 PMID： 34048010 PMCID： PMC8272439 DOI： 10.1007/978-1-0716-1488-4_9
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745