Literature DB >> 34047386

TCF-1 maintains CD8+ T cell stemness in tumor microenvironment.

Shuqiong Wen1, Huanzi Lu1, Dikan Wang1, Junyi Guo1, Wenxiao Dai1, Zhi Wang1.   

Abstract

T cell factor 1 (TCF-1) is a transcription factor (TF) of the canonical Wnt signaling pathway that encoded by the Tcf7. The crucial role of TCF-1 in T cell development and memory formation has been widely recognized. Recent studies have demonstrated that exhausted CD8+ T cell with the expression of TCF-1 may have inspiring function to amplify immunoreaction and improve the response to immunotherapy in chronic viral infection and cancer. In this short review, we summarized recent progress in intratumoral exhausted CD8+ T cells expressing TCF-1 that represent a fantastic subset with stem cell-like properties that associated with improved antitumor immunity and response to immune checkpoint blockade (ICB). ©2021 Society for Leukocyte Biology.

Entities:  

Keywords:  T cell factor 1 (TCF-1); cancer immunotherapy; progenitor exhausted T cell; stemness

Year:  2021        PMID： 34047386     DOI： 10.1002/JLB.5MR1120-778R

Source DB:  PubMed          Journal:  J Leukoc Biol        ISSN： 0741-5400            Impact factor:   4.962


  6 in total

1.  CDK4/6 blockade provides an alternative approach for treatment of mismatch-repair deficient tumors.

Authors:  Inken Salewski; Julia Henne; Leonie Engster; Paula Krone; Bjoern Schneider; Caterina Redwanz; Heiko Lemcke; Larissa Henze; Christian Junghanss; Claudia Maletzki
Journal:  Oncoimmunology       Date:  2022-07-11       Impact factor: 7.723

2.  Combinatorial immunotherapy induces tumor-infiltrating CD8+ T cells with distinct functional, migratory, and stem-like properties.

Authors:  Natalija Van Braeckel-Budimir; Joseph Samuel Dolina; Jie Wei; Xiao Wang; Shih-Hsun Chen; Pamela Santiago; Guanghuan Tu; Luca Micci; Amir A Al-Khami; Sophia Pfister; Sripad Ram; Purnima Sundar; Graham Thomas; Hua Long; Wenjing Yang; Shobha Potluri; Shahram Salek-Ardakani
Journal:  J Immunother Cancer       Date:  2021-12       Impact factor: 13.751

3.  Correlation Between TCF7+ T Cells and Prognosis of Patients With Oral Squamous Cell Carcinoma.

Authors:  Haixu Rong; Tingting Cai; Yu Peng; Xiaojuan Wang; Tianjun Lan; Zhanpeng Ou; Ling Qiu; Qunxing Li; Lizao Zhang; Fan Wu; Hsinyu Lin; Siqi Ren; Zitian Li; Song Fan; Jinsong Li
Journal:  Front Oncol       Date:  2022-03-08       Impact factor: 6.244

4.  A comprehensive profile of TCF1+ progenitor and TCF1- terminally exhausted PD-1+CD8+ T cells in head and neck squamous cell carcinoma: implications for prognosis and immunotherapy.

Authors:  Dikan Wang; Juan Fang; Shuqiong Wen; Qunxing Li; Jinming Wang; Lisa Yang; Wenxiao Dai; Huanzi Lu; Junyi Guo; Zhongyan Shan; Wenqiang Xie; Xiangqi Liu; Liling Wen; Jie Shen; Anxun Wang; Qianming Chen; Zhi Wang
Journal:  Int J Oral Sci       Date:  2022-02-14       Impact factor: 6.344

5.  Immunotherapeutic Value of Transcription Factor 19 (TCF19) Associated with Renal Clear Cell Carcinoma: A Comprehensive Analysis of 33 Human Cancer Cases.

Authors:  Xiaobao Cheng; Jian Hou; Xiangyang Wen; Runan Dong; Zhenquan Lu; Yi Jiang; Guoqing Wu; Yuan Yuan
Journal:  J Oncol       Date:  2022-09-06       Impact factor: 4.501

Review 6.  T-cell exhaustion in immune-mediated inflammatory diseases: New implications for immunotherapy.

Authors:  Zhanyan Gao; Yang Feng; Jinhua Xu; Jun Liang
Journal:  Front Immunol       Date:  2022-09-23       Impact factor: 8.786
  6 in total

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