Gregory J Botwin1,2, Dalin Li1,2, Jane Figueiredo2,3, Susan Cheng4, Jonathan Braun1,2,5, Dermot P B McGovern1,2,5, Gil Y Melmed1,2. 1. Inflammatory Bowel and Immunobiology Research Institute, Karsh Division of Digestive and Liver Diseases, Los Angeles, California, USA. 2. Department of Medicine, Cedars-Sinai, Los Angeles, California, USA. 3. Samuel Oschin Comprehensive Cancer Institute, Los Angeles, California, USA. 4. Department of Cardiology, Smidt Heart Institute, Cedars-Sinai, Los Angeles, California, USA. 5. Department of Biomedical Sciences, Cedars-Sinai, Los Angeles, California, USA.
Abstract
INTRODUCTION: Patients with immune-mediated inflammatory diseases such as inflammatory bowel disease (IBD) on immunosuppressive and biologic therapies were largely excluded from severe acute respiratory syndrome coronavirus-2 messenger RNA vaccine trials. METHODS: We evaluated adverse events (AE) after messenger RNA vaccination in 246 adults with IBD participating in a longitudinal vaccine registry. RESULTS: In general, AE frequency was similar to that reported in the general population. AEs were more common among younger patients and those with previous COVID-19. AEs were less common in individuals receiving advanced therapies with biologics or small-molecule inhibitors. DISCUSSION: Those with IBD and other immune-mediated inflammatory diseases can be reassured that the AE risk is likely not increased, and may be reduced, while on advanced therapies.
INTRODUCTION: Patients with immune-mediated inflammatory diseases such as inflammatory bowel disease (IBD) on immunosuppressive and biologic therapies were largely excluded from severe acute respiratory syndrome coronavirus-2 messenger RNA vaccine trials. METHODS: We evaluated adverse events (AE) after messenger RNA vaccination in 246 adults with IBD participating in a longitudinal vaccine registry. RESULTS: In general, AE frequency was similar to that reported in the general population. AEs were more common among younger patients and those with previous COVID-19. AEs were less common in individuals receiving advanced therapies with biologics or small-molecule inhibitors. DISCUSSION: Those with IBD and other immune-mediated inflammatory diseases can be reassured that the AE risk is likely not increased, and may be reduced, while on advanced therapies.
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