| Literature DB >> 34046597 |
Brooke X C Kwai1, Annabelle J Collins1, Martin J Middleditch2,3, Jonathan Sperry1, Ghader Bashiri2,4, Ivanhoe K H Leung1,4.
Abstract
Itaconate is a mammalian antimicrobial metabolite that inhibits the isocitrate lyases (ICLs) of Mycobacterium tuberculosis. Herein, we report that ICLs form a covalent adduct with itaconate through their catalytic cysteine residue. These results reveal atomic details of itaconate inhibition and provide insights into the catalytic mechanism of ICLs. This journal is © The Royal Society of Chemistry.Entities:
Year: 2020 PMID： 34046597 PMCID： PMC8130629 DOI： 10.1039/d0md00301h
Source DB: PubMed Journal: RSC Med Chem ISSN： 2632-8682