| Literature DB >> 34044272 |
Maryam Mahjoubin-Tehran1, Samaneh Rezaei1, Amin Jesmani2, Nafise Birang3, Korosh Morshedi4, Hashem Khanbabaei5, Haroon Khan6, Ashkan Piranviseh7, Majid Nejati8, Michael Aschner9, Hamed Mirzaei10.
Abstract
Non-coding RNAs (ncRNAs) have critical role in the pathophysiology as well as recovery after ischemic stroke. ncRNAs, particularly microRNAs, and the long non-coding RNAs (lncRNAs) are critical for angiogenesis and neuroprotection, and they have been suggested to be therapeutic, diagnostic and prognostic tools in cerebrovascular diseases, including stroke. Moreover, exosomes have been considered as nanocarriers capable of transferring various cargos, such as lncRNAs and miRNAs to recipient cells, with prominent inter-cellular roles in the mediation of neuro-restorative events following strokes and neural injuries. In this review, we summarize the pathogenic role of ncRNAs and exosomal ncRNAs in the stroke.Entities:
Keywords: Long non-coding RNAs; MicroRNAs; Pathogenesis; Stroke
Year: 2021 PMID： 34044272 DOI： 10.1016/j.biopha.2021.111753
Source DB: PubMed Journal: Biomed Pharmacother ISSN： 0753-3322 Impact factor: 6.529