Alex T Legocki1, Yasman Moshiri1, Emily M Zepeda2, Thomas B Gillette3, Ayesha Shariff4, Laura E Grant5, Leona Ding1, Aaron Y Lee1, Cecilia S Lee1, Kristina Tarczy-Hornoch6, Michelle T Cabrera7. 1. Department of Ophthalmology, University of Washington, Seattle, Washington. 2. Department of Ophthalmology, Dean McGee Eye Institute, Oklahoma City, Oklahoma. 3. Department of Ophthalmology, University of South Florida Eye Institute, Tampa, Florida. 4. Department of Ophthalmology, Case Western Reserve University, Cleveland, Ohio. 5. Department of Ophthalmology, Henry Ford Hospital, Detroit, Michigan. 6. Department of Ophthalmology, University of Washington, Seattle, Washington; Department of Ophthalmology, Seattle Children's Hospital, Seattle, Washington. 7. Department of Ophthalmology, University of Washington, Seattle, Washington; Department of Ophthalmology, Seattle Children's Hospital, Seattle, Washington. Electronic address: cabreram@uw.edu.
Abstract
PURPOSE: To describe dome-shaped macula and associated clinical findings in premature infants. METHODS: This prospective, observational cohort study included a consecutive sample of premature infants screened for retinopathy of prematurity (ROP) with 9-month follow-up. Handheld spectral domain optical coherence tomography (SD-OCT) was performed at the time of ROP screening. Images were assessed for dome-shaped macula, cystoid macular edema, epiretinal membrane, vitreous bands, and punctate hyperreflective vitreous opacities. Dome height measurements were performed in a subset of images. Teller visual acuity and cycloplegic refraction were performed at an adjusted age of 8-10 months. RESULTS: Of 37 infants (74 eyes; 49% male; mean gestational age 27.8 ± 3.2 weeks; mean birth weight 949 ± 284 g), 24/37 (65%) demonstrated dome-shaped macula in at least one eye (13 both eyes, 5 right eye only, and 6 left eye only). Of the 74 eyes, 26 (35%) could be reliably measured, with a mean dome height of 139.0 ± 72.3 μm (range, 54-369 μm). Presence of dome-shaped macula was associated with a diagnosis of ROP (P = 0.02; OR, 3.03; 95% CI, 1.18-7.82) and pre-plus or plus disease (P = 0.02; OR, 4.20; 95% CI, 1.05-16.78). Infants with dome-shaped macula had lower birth weight compared with those without (877 vs 1081 g; P = 0.04). No associations with other demographics, OCT findings, and 9-month refractive outcomes were found. CONCLUSIONS: Dome-shaped macula was frequently identified by handheld SD-OCT in premature infants, especially those with lower birth weight and severe ROP. The long-term clinical significance of this finding is unknown.
PURPOSE: To describe dome-shaped macula and associated clinical findings in premature infants. METHODS: This prospective, observational cohort study included a consecutive sample of premature infants screened for retinopathy of prematurity (ROP) with 9-month follow-up. Handheld spectral domain optical coherence tomography (SD-OCT) was performed at the time of ROP screening. Images were assessed for dome-shaped macula, cystoid macular edema, epiretinal membrane, vitreous bands, and punctate hyperreflective vitreous opacities. Dome height measurements were performed in a subset of images. Teller visual acuity and cycloplegic refraction were performed at an adjusted age of 8-10 months. RESULTS: Of 37 infants (74 eyes; 49% male; mean gestational age 27.8 ± 3.2 weeks; mean birth weight 949 ± 284 g), 24/37 (65%) demonstrated dome-shaped macula in at least one eye (13 both eyes, 5 right eye only, and 6 left eye only). Of the 74 eyes, 26 (35%) could be reliably measured, with a mean dome height of 139.0 ± 72.3 μm (range, 54-369 μm). Presence of dome-shaped macula was associated with a diagnosis of ROP (P = 0.02; OR, 3.03; 95% CI, 1.18-7.82) and pre-plus or plus disease (P = 0.02; OR, 4.20; 95% CI, 1.05-16.78). Infants with dome-shaped macula had lower birth weight compared with those without (877 vs 1081 g; P = 0.04). No associations with other demographics, OCT findings, and 9-month refractive outcomes were found. CONCLUSIONS: Dome-shaped macula was frequently identified by handheld SD-OCT in premature infants, especially those with lower birth weight and severe ROP. The long-term clinical significance of this finding is unknown.
Authors: Ramiro S Maldonado; Eric Yuan; Du Tran-Viet; Adam L Rothman; Amy Y Tong; David K Wallace; Sharon F Freedman; Cynthia A Toth Journal: Ophthalmology Date: 2014-01-21 Impact factor: 12.079
Authors: Ramiro S Maldonado; Joseph A Izatt; Neeru Sarin; David K Wallace; Sharon Freedman; C Michael Cotten; Cynthia A Toth Journal: Invest Ophthalmol Vis Sci Date: 2010-01-13 Impact factor: 4.799
Authors: Alex T Legocki; Emily M Zepeda; Thomas B Gillette; Laura E Grant; Ayesha Shariff; Phanith Touch; Aaron Y Lee; Leona Ding; Marcela M Estrada; Kristina Tarczy-Hornoch; Cecilia S Lee; Dennis E Mayock; Kathryn L Pepple; Michelle T Cabrera Journal: Ophthalmol Retina Date: 2020-04-09