James Ting1,2, Kening Jiang2, Simo Du2, Joshua Betz2,3, Nicholas Reed2,4, Melinda C Power5, Rebecca Gottesman6, A Richey Sharrett4, Michael Griswold7, Keenan A Walker8, Edgar R Miller9,10, Frank R Lin1,2, Jennifer A Deal2,4. 1. Department of Otolaryngology-Head & Neck Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland, USA. 2. Cochlear Center for Hearing and Public Health, Johns Hopkins School of Public Health, Baltimore, Maryland, USA. 3. Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. 4. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. 5. Department of Epidemiology and Biostatistics, Milken Institute School of Public Health, George Washington University, District of Columbia, USA. 6. Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA. 7. Department of Data Science, The University of Mississippi Medical Center, Jackson, USA. 8. Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute on Aging, Baltimore, Maryland, USA. 9. Department of Medicine, Division of General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA. 10. Institute for Clinical and Translational Research, Johns Hopkins University, Baltimore, Maryland, USA.
Abstract
BACKGROUND: Hearing loss is prevalent and associated with adverse functional outcomes in older adults. Prevention thus has far-reaching implications, yet few modifiable risk factors have been identified. Hypertension may contribute to age-related hearing loss, but epidemiologic evidence is mixed. We studied a prospective cohort of 3343 individuals from the Atherosclerosis Risk in Communities study, aged 44-65 years at baseline with up to 30 years of follow-up. METHODS: Hearing was assessed in late life (2016-2017) using a better-ear audiometric pure tone average (0.5, 1, 2, 4 kHz) and the Quick Speech-in-Noise (QuickSIN) test. Hypertension was defined as systolic blood pressure ≥140 mmHg, diastolic blood pressure ≥90 mmHg, or antihypertensive medication use. Midlife hypertension was defined by hypertension at 2 consecutive visits between 1987-1989 and 1996-1998. Late-life hypertension was defined in 2016-2017. Late-life low blood pressure was defined as a systolic blood pressure less than 90 mmHg or diastolic blood pressure less than 60 mmHg, irrespective of antihypertensive medication use. Associations between blood pressure patterns from mid- to late life and hearing outcomes were assessed using multivariable-adjusted linear regression. RESULTS: Compared to persistent normotension, persistent hypertension from mid- to late life was associated with worse central auditory processing (difference in QuickSIN score = -0.66 points, 95% CI: -1.14, -0.17) but not with audiometric hearing. CONCLUSIONS: Participants with persistent hypertension had poorer late-life central auditory processing. These findings suggest that hypertension may be more strongly related to hearing-related changes in the brain than in the cochlea.
BACKGROUND: Hearing loss is prevalent and associated with adverse functional outcomes in older adults. Prevention thus has far-reaching implications, yet few modifiable risk factors have been identified. Hypertension may contribute to age-related hearing loss, but epidemiologic evidence is mixed. We studied a prospective cohort of 3343 individuals from the Atherosclerosis Risk in Communities study, aged 44-65 years at baseline with up to 30 years of follow-up. METHODS: Hearing was assessed in late life (2016-2017) using a better-ear audiometric pure tone average (0.5, 1, 2, 4 kHz) and the Quick Speech-in-Noise (QuickSIN) test. Hypertension was defined as systolic blood pressure ≥140 mmHg, diastolic blood pressure ≥90 mmHg, or antihypertensive medication use. Midlife hypertension was defined by hypertension at 2 consecutive visits between 1987-1989 and 1996-1998. Late-life hypertension was defined in 2016-2017. Late-life low blood pressure was defined as a systolic blood pressure less than 90 mmHg or diastolic blood pressure less than 60 mmHg, irrespective of antihypertensive medication use. Associations between blood pressure patterns from mid- to late life and hearing outcomes were assessed using multivariable-adjusted linear regression. RESULTS: Compared to persistent normotension, persistent hypertension from mid- to late life was associated with worse central auditory processing (difference in QuickSIN score = -0.66 points, 95% CI: -1.14, -0.17) but not with audiometric hearing. CONCLUSIONS: Participants with persistent hypertension had poorer late-life central auditory processing. These findings suggest that hypertension may be more strongly related to hearing-related changes in the brain than in the cochlea.
Authors: Elizabeth P Helzner; Jane A Cauley; Sheila R Pratt; Steven R Wisniewski; Joseph M Zmuda; Evelyn O Talbott; Nathalie de Rekeneire; Tamara B Harris; Susan M Rubin; Eleanor M Simonsick; Frances A Tylavsky; Anne B Newman Journal: J Am Geriatr Soc Date: 2005-12 Impact factor: 5.562
Authors: L J Brant; S Gordon-Salant; J D Pearson; L L Klein; C H Morrell; E J Metter; J L Fozard Journal: J Am Acad Audiol Date: 1996-06 Impact factor: 1.664
Authors: Erin Smith; Charles E Bishop; Christopher Spankovich; Dan Su; Karen Valle; John Schweinfurth Journal: Otolaryngol Head Neck Surg Date: 2018-12-11 Impact factor: 3.497
Authors: Melinda C Power; Andrea L C Schneider; Lisa Wruck; Michael Griswold; Laura H Coker; Alvaro Alonso; Clifford R Jack; David Knopman; Thomas H Mosley; Rebecca F Gottesman Journal: Alzheimers Dement Date: 2016-04-29 Impact factor: 21.566
Authors: Melinda C Power; Jonathan V Tingle; Robert I Reid; Juebin Huang; A Richey Sharrett; Josef Coresh; Michael Griswold; Kejal Kantarci; Clifford R Jack; David Knopman; Rebecca F Gottesman; Thomas H Mosley Journal: J Am Heart Assoc Date: 2017-05-18 Impact factor: 5.501