Literature DB >> 34043199

Common Marmoset Model of α-Synuclein Propagation.

Masami Masuda-Suzukake1, Aki Shimozawa1, Masashi Hashimoto1, Masato Hasegawa2.   

Abstract

The propagation of assembled α-synuclein (αS) is key to understanding the pathological mechanisms of synucleinopathies such as Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy.Here we describe a nonhuman primate model of αS propagation using common marmosets (Callithrix jacchus) with an intracerebral injection of synthetic preformed αS fibrils. This protocol enables observation of the formation of phosphorylated αS pathology and its propagation three months after the injection.

Entities:  

Keywords:  Common marmosets; Intracerebral injection; Nonhuman primates; Propagation; Synucleinopathy; α-synuclein

Year:  2021        PMID： 34043199     DOI： 10.1007/978-1-0716-1495-2_13

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  10 in total

Review 1.  Alpha-synuclein and neurodegenerative diseases.

Authors:  M Goedert
Journal:  Nat Rev Neurosci       Date:  2001-07       Impact factor: 34.870

2.  alpha-Synuclein locus triplication causes Parkinson's disease.

Authors:  A B Singleton; M Farrer; J Johnson; A Singleton; S Hague; J Kachergus; M Hulihan; T Peuralinna; A Dutra; R Nussbaum; S Lincoln; A Crawley; M Hanson; D Maraganore; C Adler; M R Cookson; M Muenter; M Baptista; D Miller; J Blancato; J Hardy; K Gwinn-Hardy
Journal:  Science       Date:  2003-10-31       Impact factor: 47.728

3.  Neurobiology: learning from marmosets.

Authors:  Vivien Marx
Journal:  Nat Methods       Date:  2016-10-31       Impact factor: 28.547

4.  Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice.

Authors:  Kelvin C Luk; Victoria Kehm; Jenna Carroll; Bin Zhang; Patrick O'Brien; John Q Trojanowski; Virginia M-Y Lee
Journal:  Science       Date:  2012-11-16       Impact factor: 47.728

5.  alpha-Synuclein is phosphorylated in synucleinopathy lesions.

Authors:  Hideo Fujiwara; Masato Hasegawa; Naoshi Dohmae; Akiko Kawashima; Eliezer Masliah; Matthew S Goldberg; Jie Shen; Koji Takio; Takeshi Iwatsubo
Journal:  Nat Cell Biol       Date:  2002-02       Impact factor: 28.824

6.  Phosphorylated alpha-synuclein is ubiquitinated in alpha-synucleinopathy lesions.

Authors:  Masato Hasegawa; Hideo Fujiwara; Takashi Nonaka; Koichi Wakabayashi; Hitoshi Takahashi; Virginia M-Y Lee; John Q Trojanowski; David Mann; Takeshi Iwatsubo
Journal:  J Biol Chem       Date:  2002-10-10       Impact factor: 5.157

7.  Brain/MINDS: A Japanese National Brain Project for Marmoset Neuroscience.

Authors:  Hideyuki Okano; Erika Sasaki; Tetsuo Yamamori; Atsushi Iriki; Tomomi Shimogori; Yoko Yamaguchi; Kiyoto Kasai; Atsushi Miyawaki
Journal:  Neuron       Date:  2016-11-02       Impact factor: 17.173

8.  Propagation of pathological α-synuclein in marmoset brain.

Authors:  Aki Shimozawa; Maiko Ono; Daisuke Takahara; Airi Tarutani; Sei Imura; Masami Masuda-Suzukake; Makoto Higuchi; Kazuhiko Yanai; Shin-Ichi Hisanaga; Masato Hasegawa
Journal:  Acta Neuropathol Commun       Date:  2017-02-02       Impact factor: 7.801

9.  Prion-like spreading of pathological α-synuclein in brain.

Authors:  Masami Masuda-Suzukake; Takashi Nonaka; Masato Hosokawa; Takayuki Oikawa; Tetsuaki Arai; Haruhiko Akiyama; David M A Mann; Masato Hasegawa
Journal:  Brain       Date:  2013-03-06       Impact factor: 13.501

10.  Pathological alpha-synuclein propagates through neural networks.

Authors:  Masami Masuda-Suzukake; Takashi Nonaka; Masato Hosokawa; Maki Kubo; Aki Shimozawa; Haruhiko Akiyama; Masato Hasegawa
Journal:  Acta Neuropathol Commun       Date:  2014-08-06       Impact factor: 7.801
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.