Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Generation of Mitochondrial Toxin Rodent Models of Parkinson's Disease Using 6-OHDA , MPTP , and Rotenone.

Literature DB >> 34043196

Generation of Mitochondrial Toxin Rodent Models of Parkinson's Disease Using 6-OHDA , MPTP , and Rotenone.

Abstract

Several animal models are employed to discover novel treatments for the symptoms of Parkinson's disease (PD). PD models can be divided into two models: neurotoxin models and genetic models. Among neurotoxins to produce PD models, 6-hydroxydopamine (6-OHDA), 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), and rotenone, which inhibit the mitochondrial complex I, are widely used. Animal models of PD using these neurotoxins are also known as mitochondrial toxin models. Here this chapter describes the preparation of these mitochondrial toxin models.

Entities: Chemical Disease

Keywords: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP); 6-Hydroxydoopamine (6-OHDA); Mitochondrial complex I; Mouse; Rat; Rotenone

Year: 2021 PMID： 34043196 DOI： 10.1007/978-1-0716-1495-2_10

Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745

38 in total

1. 6-Hydroxy-dopamine induced degeneration of central monoamine neurons.

Authors: U Ungerstedt
Journal: Eur J Pharmacol Date: 1968-12 Impact factor: 4.432

Review 2. Classic toxin-induced animal models of Parkinson's disease: 6-OHDA and MPTP.

Authors: Andreas Schober
Journal: Cell Tissue Res Date: 2004-07-28 Impact factor: 5.249

3. Absence of MPTP-induced neuronal death in mice lacking the dopamine transporter.

Authors: E Bezard; C E Gross; M C Fournier; S Dovero; B Bloch; M Jaber
Journal: Exp Neurol Date: 1999-02 Impact factor: 5.330

4. Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis.

Authors: J W Langston; P Ballard; J W Tetrud; I Irwin
Journal: Science Date: 1983-02-25 Impact factor: 47.728

5. Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity.

Authors: J A Javitch; R J D'Amato; S M Strittmatter; S H Snyder
Journal: Proc Natl Acad Sci U S A Date: 1985-04 Impact factor: 11.205

6. The organic cation transporter-3 is a pivotal modulator of neurodegeneration in the nigrostriatal dopaminergic pathway.

Authors: Mei Cui; Radha Aras; Whitney V Christian; Phillip M Rappold; Mamata Hatwar; Joseph Panza; Vernice Jackson-Lewis; Jonathan A Javitch; Nazzareno Ballatori; Serge Przedborski; Kim Tieu
Journal: Proc Natl Acad Sci U S A Date: 2009-04-29 Impact factor: 11.205

Review 7. Protective actions of the vesicular monoamine transporter 2 (VMAT2) in monoaminergic neurons.

Authors: Thomas S Guillot; Gary W Miller
Journal: Mol Neurobiol Date: 2009-03-04 Impact factor: 5.590

Review 8. Mitochondrial complex I inhibitor rotenone-induced toxicity and its potential mechanisms in Parkinson's disease models.

Authors: Nian Xiong; Xi Long; Jing Xiong; Min Jia; Chunnuan Chen; Jinsha Huang; Devina Ghoorah; Xiangquan Kong; Zhicheng Lin; Tao Wang
Journal: Crit Rev Toxicol Date: 2012-05-11 Impact factor: 5.635

Review 2. Nanotechnology-Based Drug Delivery Strategies to Repair the Mitochondrial Function in Neuroinflammatory and Neurodegenerative Diseases.

Authors: Luis F González; Lorenzo E Bevilacqua; Rodrigo Naves
Journal: Pharmaceutics Date: 2021-12-01 Impact factor: 6.321

2 in total