Literature DB >> 3404119

Dengue 2 virus envelope protein expressed by a recombinant vaccinia virus fails to protect monkeys against dengue.

V Deubel1, R M Kinney, J J Esposito, C B Cropp, A V Vorndam, T P Monath, D W Trent.   

Abstract

A cDNA copy of the dengue (DEN) 2 virus genome region encoding the virion capsid, membrane and envelope structural proteins has been inserted into vaccinia virus (VV) DNA under the control of its 11K late promoter. The DEN-2 envelope protein was expressed and processed in cells infected with the VV recombinant (VV/D2S). No DEN-2 virus antibody response was detected in mice, hamsters or monkeys vaccinated with VV/D2S. Furthermore, a viraemia was observed in recombinant-vaccinated monkeys after challenge with infectious DEN-2 virus.

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Year:  1988        PMID： 3404119     DOI： 10.1099/0022-1317-69-8-1921

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  14 in total

1.  Construction and characterization of chimeric tick-borne encephalitis/dengue type 4 viruses.

Authors:  A G Pletnev; M Bray; J Huggins; C J Lai
Journal:  Proc Natl Acad Sci U S A       Date:  1992-11-01       Impact factor: 11.205

2.  Processing of dengue virus type 2 structural proteins containing deletions in hydrophobic domains.

Authors:  A Gruenberg; P J Wright
Journal:  Arch Virol       Date:  1992       Impact factor: 2.574

3.  Expression of the structural proteins of dengue 2 virus and yellow fever virus by recombinant vaccinia viruses.

Authors:  Y S Hahn; E M Lenches; R Galler; C M Rice; J Dalrymple; J H Strauss
Journal:  Arch Virol       Date:  1990       Impact factor: 2.574

4.  Dengue virus-specific murine T-lymphocyte proliferation: serotype specificity and response to recombinant viral proteins.

Authors:  A L Rothman; I Kurane; Y M Zhang; C J Lai; F A Ennis
Journal:  J Virol       Date:  1989-06       Impact factor: 5.103

5.  Attenuated vaccinia virus-circumsporozoite protein recombinants confer protection against rodent malaria.

Authors:  D E Lanar; J A Tine; C de Taisne; M C Seguin; W I Cox; J P Winslow; L A Ware; E B Kauffman; D Gordon; W R Ballou; E Paoletti; J C Sadoff
Journal:  Infect Immun       Date:  1996-05       Impact factor: 3.441

6.  Comparative analysis of the NS 1 gene sequences of dengue-1 viruses prototype Hawaii strain and Thai isolate TH-Sman, and determination of the intratypic variation of NS 1 protein among dengue-1 viruses.

Authors:  S Y Shiu; K W Ip; E A Gould; K M Chan
Journal:  Arch Virol       Date:  1993       Impact factor: 2.574

7.  Signal peptidase cleavage at the flavivirus C-prM junction: dependence on the viral NS2B-3 protease for efficient processing requires determinants in C, the signal peptide, and prM.

Authors:  C E Stocks; M Lobigs
Journal:  J Virol       Date:  1998-03       Impact factor: 5.103

8.  Mice immunized with recombinant vaccinia virus expressing dengue 4 virus structural proteins with or without nonstructural protein NS1 are protected against fatal dengue virus encephalitis.

Authors:  M Bray; B T Zhao; L Markoff; K H Eckels; R M Chanock; C J Lai
Journal:  J Virol       Date:  1989-06       Impact factor: 5.103

9.  New mouse model for dengue virus vaccine testing.

Authors:  A J Johnson; J T Roehrig
Journal:  J Virol       Date:  1999-01       Impact factor: 5.103

10.  Protective efficacy in mice of a secreted form of recombinant dengue-2 virus envelope protein produced in baculovirus infected insect cells.

Authors:  C Delenda; M P Frenkiel; V Deubel
Journal:  Arch Virol       Date:  1994       Impact factor: 2.574
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