| Literature DB >> 34038132 |
Wei Jiang1,2, Dongdong Wang2, Brice A P Wilson2, Donna Voeller3, Heidi R Bokesch2,4, Emily A Smith2,4, Stanley Lipkowitz3, Barry R O'Keefe2,5, Kirk R Gustafson2.
Abstract
An extract of a Sinularia sp. soft coral showed inhibitory activity against the E3-ubiquitin ligase casitas B-lineage lymphoma proto-oncogene B (Cbl-b). Subsequent bioassay-guided separation of the extract provided a series of terpenoid-derived spermidine and spermine amides that were named sinularamides A-G (1-7). Compounds 1-7 represent new natural products; however, sinularamide A (1) was previously reported as a synthetic end product. The structures of sinularamides A-G (1-7) were elucidated by analysis of spectroscopic and spectrometric data from NMR, IR, and HRESIMS experiments and by comparison with literature data. All of the isolated compounds showed Cbl-b inhibitory activities with IC50 values that ranged from approximately 6.5 to 33 μM.Entities:
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Year: 2021 PMID： 34038132 PMCID： PMC9341130 DOI： 10.1021/acs.jnatprod.1c00367
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.803