Paul Ferenczi1,2, Thierry Couffinhal3, Adel Mamou4, Yassine Mamou4, Quentin Ceyrat5,6, Laurence Bordenave5, Pierre Coste3, Jean-Baptiste Pinaquy5. 1. Nuclear Imaging Department, CHU de Bordeaux, 33000, Bordeaux, France. paul.ferenczi@hotmail.fr. 2. Nuclear imaging Department, CH de Pau, 64000, Pau, France. paul.ferenczi@hotmail.fr. 3. Cardiology Department, CHU de Bordeaux, 33000, Bordeaux, France. 4. R&D, NeuralX, 34000, Montpellier, France. 5. Nuclear Imaging Department, CHU de Bordeaux, 33000, Bordeaux, France. 6. Centre Imagerie Fonctionnelle, 33000, Bordeaux, France.
Abstract
OBJECTIVES: Study designed to test association between stress-induced myocardial blood flow (sMBF), resting MBF (rMBF), and MBF reserve (MFR) and coronary artery disease (CAD) in a population of CAD and non-coronary patients. Secondary objectives were to confront visual analysis and dynamic analysis and to explore potential association between MBF and several cardiovascular risk factors METHODS: A total of 155 patients who underwent dynamic myocardial perfusion imaging on a CZT camera were included. sMBF, rMBF, and MFR were evaluated, and cardiovascular risk was assessed. RESULTS: Significantly lower total sMBF and MFR were observed in CAD patient vs non-CAD patient. In comparison with visual analysis, lower sMBF were found in pathologic territory, lower rMBF in necrotic territory and lower MFR in necrotic ones. A significant correlation between total sMBF, rMBF and diabetes was found. CONCLUSION: sMBF and MFR as assessed on CZT gamma-cameras can be used to determine the coronary state. Low total sMBF might be an independent risk factor of coronaropathy. An inverse correlation was suggested between total sMBF and rMBF with diabetes.
OBJECTIVES: Study designed to test association between stress-induced myocardial blood flow (sMBF), resting MBF (rMBF), and MBF reserve (MFR) and coronary artery disease (CAD) in a population of CAD and non-coronary patients. Secondary objectives were to confront visual analysis and dynamic analysis and to explore potential association between MBF and several cardiovascular risk factors METHODS: A total of 155 patients who underwent dynamic myocardial perfusion imaging on a CZT camera were included. sMBF, rMBF, and MFR were evaluated, and cardiovascular risk was assessed. RESULTS: Significantly lower total sMBF and MFR were observed in CAD patient vs non-CAD patient. In comparison with visual analysis, lower sMBF were found in pathologic territory, lower rMBF in necrotic territory and lower MFR in necrotic ones. A significant correlation between total sMBF, rMBF and diabetes was found. CONCLUSION: sMBF and MFR as assessed on CZT gamma-cameras can be used to determine the coronary state. Low total sMBF might be an independent risk factor of coronaropathy. An inverse correlation was suggested between total sMBF and rMBF with diabetes.
Authors: Marc Dewey; Maria Siebes; Marc Kachelrieß; Klaus F Kofoed; Pál Maurovich-Horvat; Konstantin Nikolaou; Wenjia Bai; Andreas Kofler; Robert Manka; Sebastian Kozerke; Amedeo Chiribiri; Tobias Schaeffter; Florian Michallek; Frank Bengel; Stephan Nekolla; Paul Knaapen; Mark Lubberink; Roxy Senior; Meng-Xing Tang; Jan J Piek; Tim van de Hoef; Johannes Martens; Laura Schreiber Journal: Nat Rev Cardiol Date: 2020-02-24 Impact factor: 32.419