Xiangyu Guo1, Xue Li1, Chunjuan Liao1, Kun He1, Yisi Zhong1, Tao He2. 1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, 610000, China. 2. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, 610000, China. he_tao6688@126.com.
Abstract
OBJECTIVES: To investigate the therapeutic effect of a novel bioactive glass-ceramics (BGC) called Huaxi BGC (HX-BGC) on early caries lesions. MATERIALS AND METHODS: A total of 195 patients who meeting inclusion criteria were recruited and randomized to three groups in a 1:1:1 ratio. The patients in the treatment group received fluoride varnish which contained 5% sodium fluoride (NaF) or distilled water which contained 7.5% HX-BGC once a month for 3 months, and the control group received placebos. Quantitative light-induced fluorescence (QLF) images were taken at baseline and at the 1-month and 3-month follow-ups. RESULTS: The three groups had similar baseline characteristics, including age, gender, and QLF parameters (ΔF, area, and ΔQ). Compared with baseline, the ΔQ values were significantly decreased in the HX-BGC and NaF groups at 1 and 3 months (p<0.005), while no statistically significant changes were found in that of the control group. After adjusting for baseline measurements, both of the 5% NaF and 7.5% HX-BGC showed a significant therapeutic effect in the treatment of initial enamel lesions at 1 month and 3 months, when compared to those receiving placebos (ΔQ, p<0.05). Moreover, the ΔQ value of the HX-BGC group decreased by a slightly more amount than that of the NaF group at 1 month (p=0.048). Similar trends were also found for the values of ΔF and area. CONCLUSION: Our results suggest that HX-BGC may serve as a promising bioactive material for the treatment of early caries lesions. CLINICAL RELEVANCE: HX-BGC holds a great promise to be used as a novel bioactive material for the treatment of early caries lesions.
OBJECTIVES: To investigate the therapeutic effect of a novel bioactive glass-ceramics (BGC) called Huaxi BGC (HX-BGC) on early caries lesions. MATERIALS AND METHODS: A total of 195 patients who meeting inclusion criteria were recruited and randomized to three groups in a 1:1:1 ratio. The patients in the treatment group received fluoride varnish which contained 5% sodium fluoride (NaF) or distilled water which contained 7.5% HX-BGC once a month for 3 months, and the control group received placebos. Quantitative light-induced fluorescence (QLF) images were taken at baseline and at the 1-month and 3-month follow-ups. RESULTS: The three groups had similar baseline characteristics, including age, gender, and QLF parameters (ΔF, area, and ΔQ). Compared with baseline, the ΔQ values were significantly decreased in the HX-BGC and NaF groups at 1 and 3 months (p<0.005), while no statistically significant changes were found in that of the control group. After adjusting for baseline measurements, both of the 5% NaF and 7.5% HX-BGC showed a significant therapeutic effect in the treatment of initial enamel lesions at 1 month and 3 months, when compared to those receiving placebos (ΔQ, p<0.05). Moreover, the ΔQ value of the HX-BGC group decreased by a slightly more amount than that of the NaF group at 1 month (p=0.048). Similar trends were also found for the values of ΔF and area. CONCLUSION: Our results suggest that HX-BGC may serve as a promising bioactive material for the treatment of early caries lesions. CLINICAL RELEVANCE: HX-BGC holds a great promise to be used as a novel bioactive material for the treatment of early caries lesions.
Authors: Di Zhang; Outi Leppäranta; Eveliina Munukka; Heimo Ylänen; Matti K Viljanen; Erkki Eerola; Mikko Hupa; Leena Hupa Journal: J Biomed Mater Res A Date: 2010-05 Impact factor: 4.396