Deepika Rustogi1, Anne Synnes2, Belal Alshaikh1, Shabih Hasan1, Christine Drolet3, Edith Masse4, Prashanth Murthy1, Prakesh S Shah5, Kamran Yusuf6. 1. Section of Neonatology, Department of Pediatrics, Cumming School of Medicine, University of Calgary, Alberta, Canada. 2. Division of Neonatology, Department of Pediatrics, University of British Columbia, Vancouver, Canada. 3. CHU de Quebec, University of Laval, Quebec, Canada. 4. CHU de Sherbrooke, University of Sherbrooke, Quebec, Canada. 5. Pediatrics, University of Toronto, Toronto, Canada. 6. Section of Neonatology, Department of Pediatrics, Cumming School of Medicine, University of Calgary, Alberta, Canada. kyusuf@ucalgary.ca.
Abstract
OBJECTIVE: To compare neurodevelopmental outcomes of large and appropriate for gestational age (LGA, AGA) infants <29 weeks' gestation at 18-24 months of corrected age. STUDY DESIGN: Retrospective cohort study using the Canadian Neonatal Network and Canadian Neonatal Follow-Up Network databases. Primary outcome was a composite of death or significant neurodevelopmental impairment (NDI), defined as severe cerebral palsy, Bayley III cognitive, language and motor scores of <70, need for hearing aids or cochlear implant and bilateral visual impairment. Univariate and multivariable logistic analyses were applied for outcomes. RESULTS: The study cohort comprised 170 LGA and 1738 AGA infants. There was no difference in significant NDI or individual components of the Bayley III between LGA and AGA groups. LGA was associated with the increased risk of death by follow-up, 44/170 (25.9%) vs. 320/1738 (18.4%) (aOR: 1.60 95% CI: 1.00-2.54). CONCLUSIONS: Risk of NDI was similar between LGA and AGA infants.
OBJECTIVE: To compare neurodevelopmental outcomes of large and appropriate for gestational age (LGA, AGA) infants <29 weeks' gestation at 18-24 months of corrected age. STUDY DESIGN: Retrospective cohort study using the Canadian Neonatal Network and Canadian Neonatal Follow-Up Network databases. Primary outcome was a composite of death or significant neurodevelopmental impairment (NDI), defined as severe cerebral palsy, Bayley III cognitive, language and motor scores of <70, need for hearing aids or cochlear implant and bilateral visual impairment. Univariate and multivariable logistic analyses were applied for outcomes. RESULTS: The study cohort comprised 170 LGA and 1738 AGA infants. There was no difference in significant NDI or individual components of the Bayley III between LGA and AGA groups. LGA was associated with the increased risk of death by follow-up, 44/170 (25.9%) vs. 320/1738 (18.4%) (aOR: 1.60 95% CI: 1.00-2.54). CONCLUSIONS: Risk of NDI was similar between LGA and AGA infants.
Authors: Michael S Kramer; Isabelle Morin; Hong Yang; Robert W Platt; Robert Usher; Helen McNamara; K S Joseph; Shi Wu Wen Journal: J Pediatr Date: 2002-10 Impact factor: 4.406
Authors: P E Clayton; S Cianfarani; P Czernichow; G Johannsson; R Rapaport; A Rogol Journal: J Clin Endocrinol Metab Date: 2007-01-02 Impact factor: 5.958