| Literature DB >> 34032976 |
Manuela Rocha de Menezes1, Maria Eduarda Azevêdo Acioli2, Ana Carolina Lemos da Trindade3, Suéllen Pedrosa da Silva4, Raul Emídio de Lima5, Vanessa Gabryelle da Silva Teixeira3, Luydson Richardson Silva Vasconcelos2.
Abstract
Glioblastoma (GBM) is the most common, aggressive and malignant type of glioma, with poor prognosis, despite advances in medical knowledge and technology. It's known that some microRNAs (miRNAs) can be dysregulated and associated with tumors. We aim to investigate miRNAs that may have a role as potential biomarkers in human glioblastoma. A search was performed using PubMed, LILACS and SCIELO databases to find papers from 2015 to 2020, related to human in vitro and ex vivo data. From 99 articles, 10 were eligible and 13 dysregulated miRNAs were found with description of regulation, target(s), pathway(s) and mechanism(s). The miRNAs of interest were found and seem to be involved in development and progression of glioblastoma and used as target therapies. Understanding the mechanisms in which those miRNAs are involved and their role in epigenetic pathways that lead to cancer, as well as their potential in clinical application, may improve GBM clinical outcome (CRD42020182706, 07/10/2020, retrospectively registered).Entities:
Keywords: Biomarkers; Epigenetic; Glioblastoma; Systematic review; microRNAs
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Year: 2021 PMID： 34032976 DOI： 10.1007/s11033-021-06423-9
Source DB: PubMed Journal: Mol Biol Rep ISSN： 0301-4851 Impact factor: 2.316