Michael B Hoffmann1,2, Lars Choritz3, Hagen Thieme3, Gokulraj T Prabhakaran3, Robert J Puzniak3. 1. Universitäts-Augenklinik, Otto-von-Guericke Universität, Leipziger Str. 44, 39120, Magdeburg, Deutschland. michael.hoffmann@med.ovgu.de. 2. Center for Behavioral Brain Sciences, 39120, Magdeburg, Deutschland. michael.hoffmann@med.ovgu.de. 3. Universitäts-Augenklinik, Otto-von-Guericke Universität, Leipziger Str. 44, 39120, Magdeburg, Deutschland.
Abstract
BACKGROUND: Retinal pathologies affect the structure and function of post-retinal visual pathways. These post-retinal alterations bear the potential to obstruct the aim of innovative retinal treatment to restore visual function. OBJECTIVE: Current developments in the field of neuroimaging and the associated neurocomputational approaches enable a detailed assessment of this interrelationship. As a consequence, they open up the possibility to anticipate the success of treatment. METHODS: This review article demonstrates how innovations particularly in magnetic resonance imaging (MRI)-based anatomical, functional, and diffusion imaging can guide visual pathway assessments that are relevant for ophthalmological applications. RESULTS: Specific examples of retinal and visual pathway pathologies in the context of a detailed analysis of the visual pathway are described. CONCLUSION: A concept is introduced of how to translate the meaningful but technically and computationally challenging neuroimaging procedures into a clinical setting in order to effectively connect these procedures to innovative treatment approaches.
BACKGROUND: Retinal pathologies affect the structure and function of post-retinal visual pathways. These post-retinal alterations bear the potential to obstruct the aim of innovative retinal treatment to restore visual function. OBJECTIVE: Current developments in the field of neuroimaging and the associated neurocomputational approaches enable a detailed assessment of this interrelationship. As a consequence, they open up the possibility to anticipate the success of treatment. METHODS: This review article demonstrates how innovations particularly in magnetic resonance imaging (MRI)-based anatomical, functional, and diffusion imaging can guide visual pathway assessments that are relevant for ophthalmological applications. RESULTS: Specific examples of retinal and visual pathway pathologies in the context of a detailed analysis of the visual pathway are described. CONCLUSION: A concept is introduced of how to translate the meaningful but technically and computationally challenging neuroimaging procedures into a clinical setting in order to effectively connect these procedures to innovative treatment approaches.
Authors: Ruth Hamilton; Michael Bach; Sven P Heinrich; Michael B Hoffmann; J Vernon Odom; Daphne L McCulloch; Dorothy A Thompson Journal: Doc Ophthalmol Date: 2020-07-16 Impact factor: 2.379
Authors: Michael B Hoffmann; Sven P Heinrich; Hagen Thieme; Khaldoon O Al-Nosairy Journal: Klin Monbl Augenheilkd Date: 2018-11-20 Impact factor: 0.700
Authors: Khazar Ahmadi; Alessio Fracasso; Robert J Puzniak; Andre D Gouws; Renat Yakupov; Oliver Speck; Joern Kaufmann; Franco Pestilli; Serge O Dumoulin; Antony B Morland; Michael B Hoffmann Journal: Neuroimage Date: 2020-04-08 Impact factor: 6.556
Authors: Anthony G Robson; Josefin Nilsson; Shiying Li; Subhadra Jalali; Anne B Fulton; Alma Patrizia Tormene; Graham E Holder; Scott E Brodie Journal: Doc Ophthalmol Date: 2018-02-03 Impact factor: 2.379