Literature DB >> 340324

Effect of cimetidine on intrinsic factor and pepsin secretion in man.

H J Binder, R M Donaldson.   

Abstract

The effect of cimetidine on gastric acid, pepsin, and intrinsic factor secretion was assessed in normal male subjects. Cimetidine (300 mg) completely inhibited acid, pepsin, and intrinsic factor concentration and output stimulated by betazole. In contrast, basal output of pepsin and intrinsic factor was not inhibited. We conclude that H2-receptor antagonists inhibit betazole stimulation of intrinsic factor output in addition to their well-known inhibition of acid secretion.

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Year:  1978        PMID： 340324

Source DB:  PubMed          Journal:  Gastroenterology        ISSN： 0016-5085            Impact factor:   22.682


  14 in total

1.  A lyophilized aqueous extract of Maytenus ilicifolia leaves inhibits histamine-mediated acid secretion in isolated frog gastric mucosa.

Authors:  Patrícia Maria Ferreira; César Nonato de Oliveira; Alaide Braga de Oliveira; Miguel José Lopes; Fernando Alzamora; Maria Aparecida Ribeiro Vieira
Journal:  Planta       Date:  2004-03-10       Impact factor: 4.116

Review 2.  Haematological adverse effects of histamine H2-receptor antagonists.

Authors:  J P Aymard; B Aymard; P Netter; B Bannwarth; P Trechot; F Streiff
Journal:  Med Toxicol Adverse Drug Exp       Date:  1988 Nov-Dec

Review 3.  Treatment of duodenal ulceration: reflections, recollections, and reminiscences.

Authors:  K D Bardhan
Journal:  Gut       Date:  1989-11       Impact factor: 23.059

4.  Pepsin fibrinolysis of artificial clots made from fibrinogen concentrate and bovine thrombin: the effect of pH and epsilon aminocaproic acid.

Authors:  G A Valenzuela; W D Spotnitz; D D Stone
Journal:  Surg Endosc       Date:  1989       Impact factor: 4.584

5.  Effect of single and repeated doses of oral omeprazole on gastric acid and pepsin secretion and fasting serum gastrin and serum pepsinogen I levels.

Authors:  H P Festen; H A Tuynman; J Défize; G Pals; R R Frants; J P Straub; S G Meuwissen
Journal:  Dig Dis Sci       Date:  1986-06       Impact factor: 3.199

6.  Is intrinsic factor really affected by cimetidine?

Authors:  P C Sharpe; J Mills; M A Horton; R H Hunt; S H Vincent; G J Milton-Thompson
Journal:  Br Med J       Date:  1979-05-12

7.  Effect of chronic ranitidine treatment on secretion of intrinsic factor.

Authors:  N D Yeomans; R G Hanson; R A Smallwood; G W Mihaly; W J Louis
Journal:  Br Med J (Clin Res Ed)       Date:  1982-07-24

8.  Medical staff conference: cimetidine.

Authors:  L H Smith; B Scharschmidt
Journal:  West J Med       Date:  1979-11

9.  Malabsorption of protein-bound cobalamin but not unbound cobalamin during cimetidine administration.

Authors:  W M Steinberg; C E King; P P Toskes
Journal:  Dig Dis Sci       Date:  1980-03       Impact factor: 3.199

Review 10.  Pathophysiological effects of long-term acid suppression in man.

Authors:  R F McCloy; R Arnold; K D Bardhan; D Cattan; E Klinkenberg-Knol; P N Maton; R H Riddell; P Sipponen; A Walan
Journal:  Dig Dis Sci       Date:  1995-02       Impact factor: 3.199
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