Literature DB >> 3403044

Modulation of pulmonary inflammation after endotoxin inhalation with a platelet-activating factor antagonist (48740 RP).

R Rylander1, L Beijer, R C Lantz, R Burrell, P Sedivy.   

Abstract

An acute pulmonary response was induced in guinea pigs and hamsters by inhalation of bacterial endotoxin in the form of a purified lipopolysaccharide (LPS). Pretreatment with the platelet-activating factor (PAF) antagonist, 48740 RP, inhibited damage to endothelial cells, decreased vascular permeability and the number of neutrophils in the airways 24 h after exposure to LPS. The increase in the number of platelets in the airways caused by endotoxin was not affected. The results suggest that PAF modulates early inflammation after endotoxin inhalation.

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Year:  1988        PMID： 3403044     DOI： 10.1159/000234588

Source DB:  PubMed          Journal:  Int Arch Allergy Appl Immunol        ISSN： 0020-5915


  7 in total

1.  Participation of collagenase and elastase in LPS-induced airway hyperresponsiveness in guinea pigs.

Authors:  H Nagai; F Tsuji; T Shimazawa; S Goto; K Yoshitake; A Koda
Journal:  Inflammation       Date:  1991-08       Impact factor: 4.092

Review 2.  Animal models for testing anti-inflammatory drugs for treatment of bronchial hyperreactivity in asthma.

Authors:  M J Linssen; O H Wilhelms; H Timmerman
Journal:  Pharm Weekbl Sci       Date:  1991-12-13

3.  Airway oedema and obstruction in guinea pigs exposed to inhaled endotoxin.

Authors:  T Gordon; J Balmes; J Fine; D Sheppard
Journal:  Br J Ind Med       Date:  1991-09

4.  Effect of murine recombinant interleukin-5 on the cell population in guinea-pig airways.

Authors:  T Iwama; H Nagai; H Suda; N Tsuruoka; A Koda
Journal:  Br J Pharmacol       Date:  1992-01       Impact factor: 8.739

Review 5.  Byssinosis: a review.

Authors:  R McL Niven; C A Pickering
Journal:  Thorax       Date:  1996-06       Impact factor: 9.139

6.  Effects of CIS-19, a novel PAF receptor antagonist, on PAF-induced eosinophil recruitment and enhancement of superoxide anion generation in guinea-pigs.

Authors:  C M Teng; C H Lin; H P Kuo; F N Ko; H Ishii; T Ishikawa; I S Chen
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-05       Impact factor: 3.000

7.  LPS-induced 111In-eosinophil accumulation in guinea-pig skin: evidence for a role for TNF-alpha.

Authors:  V B Weg; D T Walsh; L H Faccioli; T J Williams; M Feldmann; S Nourshargh
Journal:  Immunology       Date:  1995-01       Impact factor: 7.397
  7 in total

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