| Literature DB >> 34028756 |
Jiannan Li1, Dina Dejanovic1, Megan T Zangara1, Jyotsna Chandra1, Christine McDonald1, Florian Rieder2,3.
Abstract
Mouse models are essential for investigation of underlying disease mechanisms that drive intestinal fibrosis, as well as assessment of potential therapeutic approaches to either prevent or resolve fibrosis. Here we describe several common mouse models of intestinal inflammation and fibrosis, including chemically driven colitis models, a bacterially triggered colitis model, and spontaneous intestinal inflammation in genetically susceptible mouse strains. Detailed protocols are provided for dextran sodium sulfate (DSS) colitis, 2,4,6-trinitro-benzene sulfonic acid (TNBS) colitis, adherent-invasive Escherichia coli (AIEC)-triggered colitis, the interleukin-10 knockout (IL-10KO) mouse model of spontaneous colitis, and the SAMP/YitFc model of spontaneous ileocolitis.Entities:
Keywords: 2,4,6-Trinitro-benzene sulfonic acid (TNBS); Adherent-invasive Escherichia coli (AIEC)-triggered colitis; Dextran sodium sulfate (DSS); IL-10 knockout; Mouse models; SAMP/YitFc
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Year: 2021 PMID： 34028756 PMCID： PMC8844945 DOI： 10.1007/978-1-0716-1382-5_26
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745