| Literature DB >> 34028752 |
Rafael Kramann1,2, Sylvia Menzel3.
Abstract
Chronic kidney disease (CKD) affects over 10% of the worldwide population and kidney fibrosis is a main driver of CKD and considered a therapeutic target. The mechanisms leading to kidney fibrosis are highly complexed and can be best studied in rodent models. Here we describe the most commonly used kidney fibrosis models in mice, the unilateral ureteral obstruction (UUO) model and the ischemia reperfusion injury (IRI) model. Both models are easy to learn and can be applied in animals of different age, sex, and strain.Entities:
Keywords: Hydronephrosis; IRI; Mouse model; UUO; Unilateral ischemia reperfusion
Year: 2021 PMID： 34028752 DOI： 10.1007/978-1-0716-1382-5_22
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745