Amélie Keller1,2, Fanney Thorsteinsdottir3, Maria Stougaard3,4, Isabel Cardoso3, Peder Frederiksen3, Arieh S Cohen5, Allan Vaag6, Ramune Jacobsen3,7, Berit L Heitmann3,8,9. 1. Research Unit for Dietary Studies, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark. amelie.cleo.keller@regionh.dk. 2. Section of Epidemiology, Department of Public Health, University of Copenhagen, Copenhagen, Denmark. amelie.cleo.keller@regionh.dk. 3. Research Unit for Dietary Studies, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark. 4. Center for Early Interventions and Family Studies, Department of Psychology, University of Copenhagen, Copenhagen, Denmark. 5. Statens Serum Institute, Clinical Mass Spectrometry, Copenhagen, Denmark. 6. Steno Diabetes Center Copenhagen, Gentofte, Denmark. 7. Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark. 8. The Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders, University of Sydney, Sydney, Australia. 9. Department of Public Health, Section for General Practice, University of Copenhagen, Copenhagen, Denmark.
Abstract
AIMS/HYPOTHESIS: The aim of this study was to examine the influence of neonatal vitamin D concentration on the development of early-onset type 2 diabetes in a large population sample. METHODS: We conducted a case-cohort study utilising data from the Danish biobank and registers. Neonatal vitamin D was assessed measuring 25-hydroxyvitamin D3 [25(OH)D3] concentrations on the dried blood spot samples from the Biological Specimen Bank for Neonatal Screening. Cases of type 2 diabetes (n = 731) were retrieved from the Danish National Patient Register for all individuals born in Denmark between 1 May 1981 and 31 December 1992. The sub-cohort (n = 1765) was randomly selected from all children born in the same period. We used a weighted Cox proportional hazard model assessing the hazard of first type 2 diabetes diagnoses by quintiles of 25(OH)D3 and restricted cubic spline. RESULTS: The median 25(OH)D3 concentration (IQR) among cases was 21.3 nmol/l (13.3-34.1) and 23.9 nmol/l (13.7-35.7) in the sub-cohort. There was no indication of a potential lower risk of early-onset type 2 diabetes among individuals in the higher quintile of vitamin D concentration compared with the lowest (HRcrude 0.97 [95% CI 0.71, 1.33] p = 0.85; HRadjusted 1.29 [95% CI 0.92, 1.83] p = 0.14). CONCLUSIONS/ INTERPRETATION: The results of this study do not support the hypothesis that higher neonatal vitamin D concentrations are associated with a lower risk of early-onset type 2 diabetes in adulthood.
AIMS/HYPOTHESIS: The aim of this study was to examine the influence of neonatal vitamin D concentration on the development of early-onset type 2 diabetes in a large population sample. METHODS: We conducted a case-cohort study utilising data from the Danish biobank and registers. Neonatal vitamin D was assessed measuring 25-hydroxyvitamin D3 [25(OH)D3] concentrations on the dried blood spot samples from the Biological Specimen Bank for Neonatal Screening. Cases of type 2 diabetes (n = 731) were retrieved from the Danish National Patient Register for all individuals born in Denmark between 1 May 1981 and 31 December 1992. The sub-cohort (n = 1765) was randomly selected from all children born in the same period. We used a weighted Cox proportional hazard model assessing the hazard of first type 2 diabetes diagnoses by quintiles of 25(OH)D3 and restricted cubic spline. RESULTS: The median 25(OH)D3 concentration (IQR) among cases was 21.3 nmol/l (13.3-34.1) and 23.9 nmol/l (13.7-35.7) in the sub-cohort. There was no indication of a potential lower risk of early-onset type 2 diabetes among individuals in the higher quintile of vitamin D concentration compared with the lowest (HRcrude 0.97 [95% CI 0.71, 1.33] p = 0.85; HRadjusted 1.29 [95% CI 0.92, 1.83] p = 0.14). CONCLUSIONS/ INTERPRETATION: The results of this study do not support the hypothesis that higher neonatal vitamin D concentrations are associated with a lower risk of early-onset type 2 diabetes in adulthood.
Entities:
Keywords:
25(OH)D; Case-cohort; Fetal programming; Neonatal; Type 2 diabetes; Vitamin D
Authors: Giuseppina Imperatore; James P Boyle; Theodore J Thompson; Doug Case; Dana Dabelea; Richard F Hamman; Jean M Lawrence; Angela D Liese; Lenna L Liu; Elizabeth J Mayer-Davis; Beatriz L Rodriguez; Debra Standiford Journal: Diabetes Care Date: 2012-12 Impact factor: 19.112