Literature DB >> 34027051

A mTORC1-mediated cyst(e)ine sensing mechanism governing GPX4 synthesis and ferroptosis.

Yuelong Yan1, Guang Lei1, Boyi Gan1,2.   

Abstract

Ferroptosis is a cell death mechanism triggered by lipid peroxidation. Our recent study linked cyst(e)ine availability with glutathione peroxidase 4 (GPX4) protein synthesis and ferroptosis mitigation via a Rag-mechanistic target of rapamycin complex 1 (mTORC1) axis, and proposed that co-targeting mTORC1 and ferroptosis is a promising strategy for cancer therapy.
© 2021 Taylor & Francis Group, LLC.

Entities:  

Keywords:  GPX4; SLC7A11; cancer therapy; cysteine; cystine; ferroptosis; lipid peroxidation; mTORC1

Year:  2021        PMID： 34027051      PMCID： PMC8128196          DOI： 10.1080/23723556.2021.1919006

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis.

Authors:  Junmei Yi; Jiajun Zhu; Jiao Wu; Craig B Thompson; Xuejun Jiang
Journal:  Proc Natl Acad Sci U S A       Date:  2020-11-23       Impact factor: 11.205

2.  Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion.

Authors:  Isaac S Harris; Jennifer E Endress; Jonathan L Coloff; Laura M Selfors; Samuel K McBrayer; Jennifer M Rosenbluth; Nobuaki Takahashi; Sabin Dhakal; Vidyasagar Koduri; Matthew G Oser; Nathan J Schauer; Laura M Doherty; Andrew L Hong; Yun Pyo Kang; Scott T Younger; John G Doench; William C Hahn; Sara J Buhrlage; Gina M DeNicola; William G Kaelin; Joan S Brugge
Journal:  Cell Metab       Date:  2019-02-21       Impact factor: 27.287

Review 3.  mTOR Signaling in Growth, Metabolism, and Disease.

Authors:  Robert A Saxton; David M Sabatini
Journal:  Cell       Date:  2017-03-09       Impact factor: 41.582

Review 4.  Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease.

Authors:  Brent R Stockwell; José Pedro Friedmann Angeli; Hülya Bayir; Ashley I Bush; Marcus Conrad; Scott J Dixon; Simone Fulda; Sergio Gascón; Stavroula K Hatzios; Valerian E Kagan; Kay Noel; Xuejun Jiang; Andreas Linkermann; Maureen E Murphy; Michael Overholtzer; Atsushi Oyagi; Gabriela C Pagnussat; Jason Park; Qitao Ran; Craig S Rosenfeld; Konstantin Salnikow; Daolin Tang; Frank M Torti; Suzy V Torti; Shinya Toyokuni; K A Woerpel; Donna D Zhang
Journal:  Cell       Date:  2017-10-05       Impact factor: 41.582

5.  The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression.

Authors:  Guang Lei; Yilei Zhang; Pranavi Koppula; Xiaoguang Liu; Jie Zhang; Steven H Lin; Jaffer A Ajani; Qin Xiao; Zhongxing Liao; Hui Wang; Boyi Gan
Journal:  Cell Res       Date:  2020-01-16       Impact factor: 25.617

6.  Interplay between MTOR and GPX4 signaling modulates autophagy-dependent ferroptotic cancer cell death.

Authors:  Yang Liu; Yuan Wang; Jiao Liu; Rui Kang; Daolin Tang
Journal:  Cancer Gene Ther       Date:  2020-05-27       Impact factor: 5.987

7.  mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation.

Authors:  Yilei Zhang; Robert V Swanda; Litong Nie; Xiaoguang Liu; Chao Wang; Hyemin Lee; Guang Lei; Chao Mao; Pranavi Koppula; Weijie Cheng; Jie Zhang; Zhenna Xiao; Li Zhuang; Bingliang Fang; Junjie Chen; Shu-Bing Qian; Boyi Gan
Journal:  Nat Commun       Date:  2021-03-11       Impact factor: 14.919

8.  A compendium of kinetic modulatory profiles identifies ferroptosis regulators.

Authors:  Megan Conlon; Carson D Poltorack; Giovanni C Forcina; David A Armenta; Melodie Mallais; Marcos A Perez; Alex Wells; Alexis Kahanu; Leslie Magtanong; Jennifer L Watts; Derek A Pratt; Scott J Dixon
Journal:  Nat Chem Biol       Date:  2021-03-08       Impact factor: 15.040

9.  BAP1 links metabolic regulation of ferroptosis to tumour suppression.

Authors:  Yilei Zhang; Jiejun Shi; Xiaoguang Liu; Li Feng; Zihua Gong; Pranavi Koppula; Kapil Sirohi; Xu Li; Yongkun Wei; Hyemin Lee; Li Zhuang; Gang Chen; Zhen-Dong Xiao; Mien-Chie Hung; Junjie Chen; Peng Huang; Wei Li; Boyi Gan
Journal:  Nat Cell Biol       Date:  2018-09-10       Impact factor: 28.824

Review 10.  Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy.

Authors:  Pranavi Koppula; Li Zhuang; Boyi Gan
Journal:  Protein Cell       Date:  2020-10-01       Impact factor: 14.870
  10 in total
  1 in total

Review 1.  Ferroptosis in Cancer Progression: Role of Noncoding RNAs.

Authors:  Ying-Bing Zuo; Yin-Feng Zhang; Rui Zhang; Jia-Wei Tian; Xiao-Bing Lv; Rong Li; Shu-Ping Li; Meng-Die Cheng; Jing Shan; Zheng Zhao; Hui Xin
Journal:  Int J Biol Sci       Date:  2022-02-14       Impact factor: 6.580
  1 in total

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