Literature DB >> 34027042

The role of OFD1 in selective autophagy.

Brunella Franco1,2, Manuela Morleo1.   

Abstract

Autophagy is a cellular self-degradative pathway. Our study unveiled a novel mechanism mediated by OFD1, the protein mutated in Oral-Facial-Digital type I syndrome, based on selective degradation of autophagic proteins, which enables cells to calibrate their self-degradation. We demonstrated that unrestrained autophagy contributes to renal cysts observed in Ofd1 mutants.
© 2021 Taylor & Francis Group, LLC.

Entities:  

Keywords:  OFD1; Oral-Facial-Digital type I syndrome; autophagy receptor; renal cystic disease; selective autophagy

Year:  2021        PMID： 34027042      PMCID： PMC8128168          DOI： 10.1080/23723556.2021.1903291

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  9 in total

Review 1.  A brief history of autophagy from cell biology to physiology and disease.

Authors:  Noboru Mizushima
Journal:  Nat Cell Biol       Date:  2018-04-23       Impact factor: 28.824

Review 2.  mTOR Signaling in Growth, Metabolism, and Disease.

Authors:  Robert A Saxton; David M Sabatini
Journal:  Cell       Date:  2017-03-09       Impact factor: 41.582

3.  Mutational spectrum of the oral-facial-digital type I syndrome: a study on a large collection of patients.

Authors:  Clelia Prattichizzo; Marina Macca; Valeria Novelli; Giovanna Giorgio; Adriano Barra; Brunella Franco
Journal:  Hum Mutat       Date:  2008-10       Impact factor: 4.878

Review 4.  OFD Type I syndrome: lessons learned from a rare ciliopathy.

Authors:  Manuela Morleo; Brunella Franco
Journal:  Biochem Soc Trans       Date:  2020-10-30       Impact factor: 5.407

5.  Kidney-specific inactivation of Ofd1 leads to renal cystic disease associated with upregulation of the mTOR pathway.

Authors:  Alessandro Zullo; Daniela Iaconis; Adriano Barra; Alessandra Cantone; Nadia Messaddeq; Giovanbattista Capasso; Pascal Dollé; Peter Igarashi; Brunella Franco
Journal:  Hum Mol Genet       Date:  2010-05-05       Impact factor: 6.150

6.  The centrosomal OFD1 protein interacts with the translation machinery and regulates the synthesis of specific targets.

Authors:  Daniela Iaconis; Maria Monti; Mario Renda; Arianne van Koppen; Roberta Tammaro; Marco Chiaravalli; Flora Cozzolino; Paola Pignata; Claudia Crina; Piero Pucci; Alessandra Boletta; Vincenzo Belcastro; Rachel H Giles; Enrico Maria Surace; Simone Gallo; Mario Pende; Brunella Franco
Journal:  Sci Rep       Date:  2017-04-27       Impact factor: 4.379

Review 7.  History of the Selective Autophagy Research: How Did It Begin and Where Does It Stand Today?

Authors:  Vladimir Kirkin
Journal:  J Mol Biol       Date:  2019-05-11       Impact factor: 5.469

8.  Regulation of autophagosome biogenesis by OFD1-mediated selective autophagy.

Authors:  Manuela Morleo; Simona Brillante; Umberto Formisano; Luigi Ferrante; Fabrizia Carbone; Daniela Iaconis; Alessandro Palma; Viviana Buonomo; Angela Serena Maione; Paolo Grumati; Carmine Settembre; Brunella Franco
Journal:  EMBO J       Date:  2020-12-28       Impact factor: 11.598

Review 9.  A molecular perspective of mammalian autophagosome biogenesis.

Authors:  Thomas J Mercer; Andrea Gubas; Sharon A Tooze
Journal:  J Biol Chem       Date:  2018-01-25       Impact factor: 5.157
  9 in total
  1 in total

Review 1.  OFD1: One gene, several disorders.

Authors:  Nunziana Pezzella; Guglielmo Bove; Roberta Tammaro; Brunella Franco
Journal:  Am J Med Genet C Semin Med Genet       Date:  2022-02-02       Impact factor: 3.359
  1 in total

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