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Literature DB >> 34027040

Metabolic checkpoint of ferroptosis resistance.

Abstract

The metabolic checkpoint of ferroptosis remains obscure. We find that glucose favors system xc- inhibitor-induced ferroptosis by activating pyruvate oxidation, thereby promoting fatty acid synthesis and subsequent lipid peroxidation. In contrast, the upregulation of pyruvate dehydrogenase kinase 4 (PDK4) switches into a ferroptosis-resistant state in pancreatic cancer cells.

Entities: Chemical

Keywords: Ferroptosis; fatty acid synthesis; metabolic basis; pancreatic cancer; pyruvate oxidation

Year: 2021 PMID： 34027040 PMCID： PMC8128190 DOI： 10.1080/23723556.2021.1901558

Source DB: PubMed Journal: Mol Cell Oncol ISSN： 2372-3556

Keyword Cloud
References

10 in total

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Authors: Xinxin Song; Shan Zhu; Pan Chen; Wen Hou; Qirong Wen; Jiao Liu; Yangchun Xie; Jinbao Liu; Daniel J Klionsky; Guido Kroemer; Michael T Lotze; Herbert J Zeh; Rui Kang; Daolin Tang
Journal: Curr Biol Date: 2018-07-26 Impact factor: 10.834

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Authors: Shihui Hao; Bishan Liang; Qiong Huang; Shumin Dong; Zhenzhen Wu; Wanming He; Min Shi
Journal: Oncol Lett Date: 2018-02-15 Impact factor: 2.967

Review 3. Broadening horizons: the role of ferroptosis in cancer.

Authors: Xin Chen; Rui Kang; Guido Kroemer; Daolin Tang
Journal: Nat Rev Clin Oncol Date: 2021-01-29 Impact factor: 66.675

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Authors: Youbo Zhao; Menghuan Li; Xuemei Yao; Yang Fei; Zhenghong Lin; Zhengguo Li; Kaiyong Cai; Yanli Zhao; Zhong Luo
Journal: Cell Rep Date: 2020-12-08 Impact factor: 9.423

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Journal: Curr Top Med Chem Date: 2018 Impact factor: 3.295

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Authors: Changfeng Li; Ying Zhang; Jiao Liu; Rui Kang; Daniel J Klionsky; Daolin Tang
Journal: Autophagy Date: 2020-03-18 Impact factor: 16.016

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Authors: Brent R Stockwell; José Pedro Friedmann Angeli; Hülya Bayir; Ashley I Bush; Marcus Conrad; Scott J Dixon; Simone Fulda; Sergio Gascón; Stavroula K Hatzios; Valerian E Kagan; Kay Noel; Xuejun Jiang; Andreas Linkermann; Maureen E Murphy; Michael Overholtzer; Atsushi Oyagi; Gabriela C Pagnussat; Jason Park; Qitao Ran; Craig S Rosenfeld; Konstantin Salnikow; Daolin Tang; Frank M Torti; Suzy V Torti; Shinya Toyokuni; K A Woerpel; Donna D Zhang
Journal: Cell Date: 2017-10-05 Impact factor: 41.582

8. PDK4 dictates metabolic resistance to ferroptosis by suppressing pyruvate oxidation and fatty acid synthesis.

Authors: Xinxin Song; Jiao Liu; Feimei Kuang; Xin Chen; Herbert J Zeh; Rui Kang; Guido Kroemer; Yangchun Xie; Daolin Tang
Journal: Cell Rep Date: 2021-02-23 Impact factor: 9.423

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Authors: Hyemin Lee; Fereshteh Zandkarimi; Yilei Zhang; Jitendra Kumar Meena; Jongchan Kim; Li Zhuang; Siddhartha Tyagi; Li Ma; Thomas F Westbrook; Gregory R Steinberg; Daisuke Nakada; Brent R Stockwell; Boyi Gan
Journal: Nat Cell Biol Date: 2020-02-06 Impact factor: 28.824

10. Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173/STING-dependent DNA sensor pathway.

Authors: Enyong Dai; Leng Han; Jiao Liu; Yangchun Xie; Herbert J Zeh; Rui Kang; Lulu Bai; Daolin Tang
Journal: Nat Commun Date: 2020-12-11 Impact factor: 14.919