Literature DB >> 34027037

Regulation of nuclear mTORC1.

Xin Zhou1, Yanghao Zhong1,2, Jin Zhang1,3,4.   

Abstract

mTORC1 integrates diverse upstream signals to control cell growth and metabolism. We previously showed that mTORC1 activity is spatially compartmentalized to ensure its signaling specificity. In a recently published study, we demonstrated the existence of mTORC1 activity in the nucleus and identified a unique mode of its regulation in the nuclear compartment.
© 2021 Taylor & Francis Group, LLC.

Entities:  

Keywords:  RAPTOR; nuclear translocation; protein kinase; signaling specificity; spatial compartmentalization

Year:  2021        PMID： 34027037      PMCID： PMC8128192          DOI： 10.1080/23723556.2021.1896348

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  The expanding relevance of nuclear mTOR in carcinogenesis.

Authors:  Jung H Back; Arianna L Kim
Journal:  Cell Cycle       Date:  2011-11-15       Impact factor: 4.534

Review 2.  Canonical signaling and nuclear activity of mTOR-a teamwork effort to regulate metabolism and cell growth.

Authors:  Vincent Giguère
Journal:  FEBS J       Date:  2018-01-31       Impact factor: 5.542

Review 3.  Unraveling the multifaceted nature of the nuclear function of mTOR.

Authors:  Alek S Torres; Marina K Holz
Journal:  Biochim Biophys Acta Mol Cell Res       Date:  2020-11-12       Impact factor: 4.739

4.  Requirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cells.

Authors:  Boris Shor; Jiang Wu; Quazi Shakey; Lourdes Toral-Barza; Celine Shi; Max Follettie; Ker Yu
Journal:  J Biol Chem       Date:  2010-03-16       Impact factor: 5.157

5.  Dynamic Visualization of mTORC1 Activity in Living Cells.

Authors:  Xin Zhou; Terri L Clister; Pamela R Lowry; Marcus M Seldin; G William Wong; Jin Zhang
Journal:  Cell Rep       Date:  2015-03-12       Impact factor: 9.423

6.  Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome.

Authors:  Suchithra Menon; Christian C Dibble; George Talbott; Gerta Hoxhaj; Alexander J Valvezan; Hidenori Takahashi; Lewis C Cantley; Brendan D Manning
Journal:  Cell       Date:  2014-02-13       Impact factor: 41.582

7.  Ran-binding protein 3 phosphorylation links the Ras and PI3-kinase pathways to nucleocytoplasmic transport.

Authors:  Sang-Oh Yoon; Sejeong Shin; Yuzhen Liu; Bryan A Ballif; Michele S Woo; Steven P Gygi; John Blenis
Journal:  Mol Cell       Date:  2008-02-15       Impact factor: 17.970

Review 8.  mTOR at the nexus of nutrition, growth, ageing and disease.

Authors:  Grace Y Liu; David M Sabatini
Journal:  Nat Rev Mol Cell Biol       Date:  2020-01-14       Impact factor: 94.444

9.  Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus.

Authors:  Xin Zhou; Yanghao Zhong; Olivia Molinar-Inglis; Maya T Kunkel; Mingyuan Chen; Tengqian Sun; Jiao Zhang; John Y-J Shyy; JoAnn Trejo; Alexandra C Newton; Jin Zhang
Journal:  Nat Commun       Date:  2020-11-30       Impact factor: 14.919

10.  mTORC1 directly phosphorylates and activates ERα upon estrogen stimulation.

Authors:  A Alayev; R S Salamon; S M Berger; N S Schwartz; R Cuesta; R B Snyder; M K Holz
Journal:  Oncogene       Date:  2015-11-02       Impact factor: 9.867
  10 in total

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