Literature DB >> 34027036

The PIDDosome: centrosome guardian and backup on the DNA damage response.

Matteo Burigotto1, Luca L Fava1.   

Abstract

The PIDDosome is a Caspase-2-activating platform assembling in response to centrosome amplification or genotoxic stress. We have recently shown that both stimuli depend on ANKRD26 (ankyrin repeat domain-containing protein 26)-mediated localization of PIDD1 (p53-inducible protein with death domain) at the centrosome, demonstrating how this organelle can directly influence cell fate.
© 2021 Taylor & Francis Group, LLC.

Entities:  

Keywords:  DNA damage; PIDDosome; centrosome; p53

Year:  2021        PMID： 34027036      PMCID： PMC8128191          DOI： 10.1080/23723556.2021.1893625

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress.

Authors:  Antoine Tinel; Jürg Tschopp
Journal:  Science       Date:  2004-04-08       Impact factor: 47.728

Review 2.  The resurrection of the PIDDosome - emerging roles in the DNA-damage response and centrosome surveillance.

Authors:  Valentina Sladky; Fabian Schuler; Luca L Fava; Andreas Villunger
Journal:  J Cell Sci       Date:  2017-11-15       Impact factor: 5.285

3.  A Switch in p53 Dynamics Marks Cells That Escape from DSB-Induced Cell Cycle Arrest.

Authors:  Michael Tsabar; Caroline S Mock; Veena Venkatachalam; Jose Reyes; Kyle W Karhohs; Trudy G Oliver; Aviv Regev; Ashwini Jambhekar; Galit Lahav
Journal:  Cell Rep       Date:  2020-11-10       Impact factor: 9.423

4.  Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3.

Authors:  Samuel Sidi; Takaomi Sanda; Richard D Kennedy; Andreas T Hagen; Cicely A Jette; Raymond Hoffmans; Jennifer Pascual; Shintaro Imamura; Shuji Kishi; James F Amatruda; John P Kanki; Douglas R Green; Alan A D'Andrea; A Thomas Look
Journal:  Cell       Date:  2008-05-30       Impact factor: 41.582

5.  PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling.

Authors:  Kiyohiro Ando; Jennifer L Kernan; Peter H Liu; Takaomi Sanda; Emmanuelle Logette; Jurg Tschopp; A Thomas Look; Jianlong Wang; Lisa Bouchier-Hayes; Samuel Sidi
Journal:  Mol Cell       Date:  2012-07-30       Impact factor: 17.970

6.  Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop.

Authors:  Trudy G Oliver; Etienne Meylan; Gregory P Chang; Wen Xue; James R Burke; Timothy J Humpton; Diana Hubbard; Arjun Bhutkar; Tyler Jacks
Journal:  Mol Cell       Date:  2011-07-08       Impact factor: 17.970

7.  ANKRD26 recruits PIDD1 to centriolar distal appendages to activate the PIDDosome following centrosome amplification.

Authors:  Lauren T Evans; Taylor Anglen; Phillip Scott; Kimberly Lukasik; Jadranka Loncarek; Andrew J Holland
Journal:  EMBO J       Date:  2020-12-22       Impact factor: 11.598

8.  The PIDDosome activates p53 in response to supernumerary centrosomes.

Authors:  Luca L Fava; Fabian Schuler; Valentina Sladky; Manuel D Haschka; Claudia Soratroi; Lisa Eiterer; Egon Demetz; Guenter Weiss; Stephan Geley; Erich A Nigg; Andreas Villunger
Journal:  Genes Dev       Date:  2017-01-01       Impact factor: 11.361

9.  Centriolar distal appendages activate the centrosome-PIDDosome-p53 signalling axis via ANKRD26.

Authors:  Matteo Burigotto; Alessia Mattivi; Daniele Migliorati; Giovanni Magnani; Chiara Valentini; Michela Roccuzzo; Martin Offterdinger; Massimo Pizzato; Alexander Schmidt; Andreas Villunger; Stefano Maffini; Luca L Fava
Journal:  EMBO J       Date:  2020-12-22       Impact factor: 11.598

10.  BCL9L Dysfunction Impairs Caspase-2 Expression Permitting Aneuploidy Tolerance in Colorectal Cancer.

Authors:  Carlos López-García; Laurent Sansregret; Enric Domingo; Nicholas McGranahan; Sebastijan Hobor; Nicolai Juul Birkbak; Stuart Horswell; Eva Grönroos; Francesco Favero; Andrew J Rowan; Nicholas Matthews; Sharmin Begum; Benjamin Phillimore; Rebecca Burrell; Dahmane Oukrif; Bradley Spencer-Dene; Michal Kovac; Gordon Stamp; Aengus Stewart; Havard Danielsen; Marco Novelli; Ian Tomlinson; Charles Swanton
Journal:  Cancer Cell       Date:  2017-01-09       Impact factor: 38.585
  10 in total
  2 in total

Review 1.  Cell Cycle Regulation by Integrin-Mediated Adhesion.

Authors:  Siamak A Kamranvar; Bhavna Rani; Staffan Johansson
Journal:  Cells       Date:  2022-08-14       Impact factor: 7.666

Review 2.  Prevalence and natural history of variants in the ANKRD26 gene: a short review and update of reported cases.

Authors:  Hrushikesh Vyas; Ahmad Alcheikh; Gillian Lowe; William S Stevenson; Neil V Morgan; David J Rabbolini
Journal:  Platelets       Date:  2022-05-19       Impact factor: 4.236
  2 in total

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