Literature DB >> 3402528

Presence of epoxide hydrolase and glutathione S-transferase in human pulmonary alveolar macrophages.

S Petruzzelli1, P Bernard, P Paoletti, A Rane, C Giuntini, G M Pacifici.   

Abstract

Pulmonary alveolar macrophages (PAMs) were obtained from 11 patients by bronchoalveolar lavage. Epoxide hydrolase and glutathione S-transferase in sonicated PAMs were measured using benzo(a)pyrene-4,5-oxide as the substrate. The activity of epoxide hydrolase was 0.24 +/- 0.10 nmol/min/mg protein (mean +/- SD), and of glutathione S-transferase 0.22 +/- 0.12 nmol/min/mg protein. There was a significant difference in enzyme activities in the PAMs from smokers and non-smokers. Epoxides may be metabolized in PAMs.

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Year:  1988        PMID： 3402528     DOI： 10.1007/bf00542447

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  12 in total

1.  K region benzo (alpha) pyrene-4,5-oxide is conjugated by homogeneous gluthathione S-transferases.

Authors:  N Nemoto; H V Gelboin; W H Habig; J N Ketley; W B Jakoby
Journal:  Nature       Date:  1975-06-05       Impact factor: 49.962

2.  Serum glutathione S-transferases: perinatal development, sex difference, and effect of carbon tetrachloride administration on enzyme activity in the rat.

Authors:  H Mukhtar; J R Bend
Journal:  Life Sci       Date:  1977-11-01       Impact factor: 5.037

3.  Aryl hydrocarbon hydroxylase activity in pulmonary macrophages and lymphocytes from lung cancer and noncancer patients.

Authors:  T L McLemore; R R Martin; D L Busbee; R C Richie; R R Springer; K L Toppell; E T Cantrell
Journal:  Cancer Res       Date:  1977-04       Impact factor: 12.701

4.  Hepatic microsomal epoxide hydrase: a sensitive radiometric assay for hydration of arene oxides of carcinogenic aromatic hydrocarbons.

Authors:  D M Jerina; P M Dansette
Journal:  Mol Pharmacol       Date:  1977-03       Impact factor: 4.436

Review 5.  Metabolism of polycyclic aromatic hydrocarbons: etiologic role in carcinogenesis.

Authors:  O Pelkonen; D W Nebert
Journal:  Pharmacol Rev       Date:  1982-06       Impact factor: 25.468

6.  Mixed function oxidase and glutathione S-transferase activities in normal human peripheral blood lymphocytes.

Authors:  N Singh; J Clausen
Journal:  Cancer Lett       Date:  1981-06       Impact factor: 8.679

7.  Inflammatory and immune processes in the human lung in health and disease: evaluation by bronchoalveolar lavage.

Authors:  G W Hunninghake; J E Gadek; O Kawanami; V J Ferrans; R G Crystal
Journal:  Am J Pathol       Date:  1979-10       Impact factor: 4.307

8.  Monooxygenase, epoxide hydrolase, and glutathione-S-transferase activities in human lung. Variation between groups of bronchogenic carcinoma and non-cancer patients and interindividual differences.

Authors:  F Oesch; H Schmassmann; E Ohnhaus; U Althaus; J Lorenz
Journal:  Carcinogenesis       Date:  1980       Impact factor: 4.944

9.  Glutathione S-transferase activities in placentas from smoking and non-smoking women.

Authors:  D K Manchester; E H Jacoby
Journal:  Xenobiotica       Date:  1982-09       Impact factor: 1.908

10.  Lung phagocyte recruitment and metabolic alterations induced by cigarette smoke in humans and in hamsters.

Authors:  J R Hoidal; D E Niewoehner
Journal:  Am Rev Respir Dis       Date:  1982-09
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  3 in total

1.  Heterogeneous expression and polymorphic genotype of glutathione S-transferases in human lung.

Authors:  A M Cantlay; C A Smith; W A Wallace; P L Yap; D Lamb; D J Harrison
Journal:  Thorax       Date:  1994-10       Impact factor: 9.139

2.  In vitro airway models from mice, rhesus macaques, and humans maintain species differences in xenobiotic metabolism and cellular responses to naphthalene.

Authors:  Jacklyn Kelty; Nataliia Kovalchuk; Eric Uwimana; Lei Yin; Xinxin Ding; Laura Van Winkle
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2022-07-19       Impact factor: 6.011

3.  Pulmonary alveolar macrophages in molecular epidemiology and chemoprevention of cancer.

Authors:  S De Flora; A Izzotti; F D'Agostini; G A Rossi; R M Balansky
Journal:  Environ Health Perspect       Date:  1993-03       Impact factor: 9.031
  3 in total

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