Naruo Tokuyasu 1 , Masataka Amisaki 1 , Takehiko Hanaki 1 , Yuki Murakami 1 , Masaki Morimoto 1 , Ei Uchinaka 1 , Takuki Yagyu 1 , Keisuke Goto 1 , Tomoyuki Matsunaga 1 , Manabu Yamamoto 1 , Shuichi Takano 1 , Teruhisa Sakamoto 1 , Soichiro Honjo 1 , Toshimichi Hasegawa 1 , Yoshiyuki Fujiwara 1 Show Affiliations »
Abstract
BACKGROUND: As antithrombin III (AT-III) is produced in the hepatocytes, its serum activity decreases at the time of liver failure, in addition to ischemia reperfusion injury, vascular endothelial dysfunction, and disseminated intravascular coagulation (DIC). Here, we examined whether the serum AT-III value after hepatectomy could be a prognostic factor for hepatocellular carcinoma (HCC). METHODS: Of 141 patients who underwent hepatectomy for HCC, data for 101 patients in whom serum AT-III activity was measured on the first postoperative day were extracted. Patients with serum AT-III activity > 50% and ≤ 50% were assigned to high value (72 cases) and low value (29 cases) groups, respectively. We examined the clinical and prognostic differences between these two groups. RESULTS: The average age of enrolled patients (83 men and 18 women) was 68.0 years. The 5-year overall survival rate was 88% and 60% in the high and low value groups, respectively (P < 0.01). Furthermore, the 2-year relapse-free survival rate was 71% and 54% in the high and low value groups, respectively (P = 0.03). CONCLUSION: This is the first study to demonstrate that serum AT-III levels on the first postoperative day may serve as a prognostic factor in HCC patients. ©2021 Tottori University Medical Press.
BACKGROUND: As antithrombin III (AT-III) is produced in the hepatocytes, its serum activity decreases at the time of liver failure, in addition to ischemia reperfusion injury, vascular endothelial dysfunction, and disseminated intravascular coagulation (DIC). Here, we examined whether the serum AT-III value after hepatectomy could be a prognostic factor for hepatocellular carcinoma (HCC). METHODS: Of 141 patients who underwent hepatectomy for HCC, data for 101 patients in whom serum AT-III activity was measured on the first postoperative day were extracted. Patients with serum AT-III activity > 50% and ≤ 50% were assigned to high value (72 cases) and low value (29 cases) groups, respectively. We examined the clinical and prognostic differences between these two groups. RESULTS: The average age of enrolled patients (83 men and 18 women) was 68.0 years. The 5-year overall survival rate was 88% and 60% in the high and low value groups, respectively (P < 0.01). Furthermore, the 2-year relapse-free survival rate was 71% and 54% in the high and low value groups, respectively (P = 0.03). CONCLUSION: This is the first study to demonstrate that serum AT-III levels on the first postoperative day may serve as a prognostic factor in HCC patients. ©2021 Tottori University Medical Press.
Entities: Chemical
Keywords:
Antithrombin III; Hepatectomy; Hepatocellular carcinoma; Prognostic factor
Year: 2021
PMID： 34025191 PMCID： PMC8128657 DOI： 10.33160/yam.2021.05.007
Source DB: PubMed Journal: Yonago Acta Med ISSN： 0513-5710 Impact factor: 1.641