Inadequate reporting of analytical quality control in the clinical pharmacological literature.

Quality control parameters were surveyed in the clinical pharmacological literature of 1984 and 1985, as published by the European Journal of Clinical Pharmacology, the British Journal of Clinical Pharmacology, and Clinical Pharmacology and Therapeutics. Papers which included newly developed methods gave details about precision and sensitivity in more than 60% and about accuracy and specificity in nearly 30%. Fewer than one-third of all articles containing analytical methods, described by citation only, gave information about precision and sensitivity in the originating laboratory, and accuracy and specificity were reported by less than 10% of them. These data represent an important deficiency in laboratory information in the clinical pharmacological literature.