Literature DB >> 34024340

The Enigma of AHR Activation in the Skin: Interplay among Ligands, Metabolism, and Bioavailability.

Ellen H van den Bogaard1, Gary H Perdew2.   

Abstract

AHR is expressed in a variety of skin cell types and contributes to skin homeostasis. Therapeutic targeting of AHR in dermatology was first described for the treatment of inflammatory skin diseases using coal tar ointment. In addition to therapies involving active ligands such as coal tar and tapinarof, the inhibition of AHR-dependent enzymatic activities in the skin may be an alternative approach to resolving skin inflammation.
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

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Year:  2021        PMID： 34024340      PMCID： PMC8336719          DOI： 10.1016/j.jid.2020.12.013

Source DB:  PubMed          Journal:  J Invest Dermatol        ISSN： 0022-202X            Impact factor:   7.590


  10 in total

1.  Aryl Hydrocarbon Receptor in Keratinocytes Is Essential for Murine Skin Barrier Integrity.

Authors:  Katharina Haas; Heike Weighardt; René Deenen; Karl Köhrer; Björn Clausen; Sonja Zahner; Petra Boukamp; Wilhelm Bloch; Jean Krutmann; Charlotte Esser
Journal:  J Invest Dermatol       Date:  2016-07-16       Impact factor: 8.551

2.  6-Formylindolo[3,2-b]carbazole (FICZ) is a Very Minor Photoproduct of Tryptophan at Biologically Relevant Doses of UVB and Simulated Sunlight.

Authors:  Antonia Youssef; Anne von Koschembahr; Sylvain Caillat; Sebastien Corre; Marie-Dominique Galibert; Thierry Douki
Journal:  Photochem Photobiol       Date:  2018-07-12       Impact factor: 3.421

3.  Whole metagenome profiling reveals skin microbiome-dependent susceptibility to atopic dermatitis flare.

Authors:  Kern Rei Chng; Angeline Su Ling Tay; Chenhao Li; Amanda Hui Qi Ng; Jingjing Wang; Bani Kaur Suri; Sri Anusha Matta; Naomi McGovern; Baptiste Janela; Xuan Fei Colin C Wong; Yang Yie Sio; Bijin Veonice Au; Andreas Wilm; Paola Florez De Sessions; Thiam Chye Lim; Mark Boon Yang Tang; Florent Ginhoux; John E Connolly; E Birgitte Lane; Fook Tim Chew; John E A Common; Niranjan Nagarajan
Journal:  Nat Microbiol       Date:  2016-07-11       Impact factor: 17.745

4.  Inhibition of cytochrome P4501-dependent clearance of the endogenous agonist FICZ as a mechanism for activation of the aryl hydrocarbon receptor.

Authors:  Emma Wincent; Johanna Bengtsson; Afshin Mohammadi Bardbori; Tomas Alsberg; Sandra Luecke; Ulf Rannug; Agneta Rannug
Journal:  Proc Natl Acad Sci U S A       Date:  2012-03-05       Impact factor: 11.205

5.  Transgenic Humanized AHR Mouse Reveals Differences between Human and Mouse AHR Ligand Selectivity.

Authors:  Colin A Flaveny; Gary H Perdew
Journal:  Mol Cell Pharmacol       Date:  2009-01-01

6.  Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis.

Authors:  Ellen H van den Bogaard; Judith G M Bergboer; Mieke Vonk-Bergers; Ivonne M J J van Vlijmen-Willems; Stanleyson V Hato; Pieter G M van der Valk; Jens Michael Schröder; Irma Joosten; Patrick L J M Zeeuwen; Joost Schalkwijk
Journal:  J Clin Invest       Date:  2013-01-25       Impact factor: 14.808

Review 7.  Tapinarof in the treatment of psoriasis: A review of the unique mechanism of action of a novel therapeutic aryl hydrocarbon receptor-modulating agent.

Authors:  Robert Bissonnette; Linda Stein Gold; David S Rubenstein; Anna M Tallman; April Armstrong
Journal:  J Am Acad Dermatol       Date:  2020-11-03       Impact factor: 11.527

8.  CYP1A1 Enzymatic Activity Influences Skin Inflammation Via Regulation of the AHR Pathway.

Authors:  Mariela Kyoreva; Ying Li; Mariyah Hoosenally; Jonathan Hardman-Smart; Kirsten Morrison; Isabella Tosi; Mauro Tolaini; Guillermo Barinaga; Brigitta Stockinger; Ulrich Mrowietz; Frank O Nestle; Catherine H Smith; Jonathan N Barker; Paola Di Meglio
Journal:  J Invest Dermatol       Date:  2020-12-29       Impact factor: 8.551

9.  Photo-oxidation products of skin surface squalene mediate metabolic and inflammatory responses to solar UV in human keratinocytes.

Authors:  Vladimir Kostyuk; Alla Potapovich; Andrea Stancato; Chiara De Luca; Daniela Lulli; Saveria Pastore; Liudmila Korkina
Journal:  PLoS One       Date:  2012-08-30       Impact factor: 3.240
  10 in total
  2 in total

1.  Carboxamide Derivatives Are Potential Therapeutic AHR Ligands for Restoring IL-4 Mediated Repression of Epidermal Differentiation Proteins.

Authors:  Gijs Rikken; Noa J M van den Brink; Ivonne M J J van Vlijmen-Willems; Piet E J van Erp; Lars Pettersson; Jos P H Smits; Ellen H van den Bogaard
Journal:  Int J Mol Sci       Date:  2022-02-04       Impact factor: 5.923

Review 2.  More than Meets the Eye: The Aryl Hydrocarbon Receptor is an Environmental Sensor, Physiological Regulator and a Therapeutic Target in Ocular Disease.

Authors:  Christine L Hammond; Elisa Roztocil; Vardaan Gupta; Steven E Feldon; Collynn F Woeller
Journal:  Front Toxicol       Date:  2022-03-03
  2 in total

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