Literature DB >> 34024339

The Hyperglycemia Stranglehold Stifles Cutaneous Epithelial‒Mesenchymal Plasticity and Functional Wound Closure.

Chandan K Sen1, Sashwati Roy2.   

Abstract

Iterative cycles of epithelial‒mesenchymal transition (EMT) and mesenchymal-to-epithelial transition (MET) are responsible for epithelial plasticity necessary to achieve functional wound closure. Restoration of the barrier function of the repaired skin is a hallmark of functional wound closure. Both EMT and MET are subject to control by glycemic status. A new article by Tan et al (2020) supports the notion that hyperglycemia blunts epithelial plasticity.
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

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Year:  2021        PMID： 34024339      PMCID： PMC8152937          DOI： 10.1016/j.jid.2020.11.021

Source DB:  PubMed          Journal:  J Invest Dermatol        ISSN： 0022-202X            Impact factor:   7.590


  32 in total

1.  Novel cholinergic peptides SLURP-1 and -2 regulate epithelialization of cutaneous and oral wounds.

Authors:  Alexander I Chernyavsky; Mina Kalantari-Dehaghi; Courtney Phillips; Steve Marchenko; Sergei A Grando
Journal:  Wound Repair Regen       Date:  2011-12-13       Impact factor: 3.617

Review 2.  Monocyte and macrophage plasticity in tissue repair and regeneration.

Authors:  Amitava Das; Mithun Sinha; Soma Datta; Motaz Abas; Scott Chaffee; Chandan K Sen; Sashwati Roy
Journal:  Am J Pathol       Date:  2015-06-26       Impact factor: 4.307

3.  Stimulation of the Nonneuronal Cholinergic System by Highly Diluted Acetylcholine in Keratinocytes.

Authors:  Francesca Uberti; Claudio Bardelli; Vera Morsanuto; Sabrina Ghirlanda; Andrea Cochis; Claudio Molinari
Journal:  Cells Tissues Organs       Date:  2016-11-25       Impact factor: 2.481

4.  Sociogenomic Approach to Wound Care: A New Patient-Centered Paradigm.

Authors:  Chandan K Sen; Sashwati Roy
Journal:  Adv Wound Care (New Rochelle)       Date:  2019-10-16       Impact factor: 4.730

5.  RAGE mediates the inactivation of nAChRs in sympathetic neurons under high glucose conditions.

Authors:  Andrew R Chandna; Manoj Nair; Christine Chang; Paul R Pennington; Yasuhiko Yamamoto; Darrell D Mousseau; Verónica A Campanucci
Journal:  Eur J Neurosci       Date:  2014-11-28       Impact factor: 3.386

Review 6.  The pulse of inflammation: heart rate variability, the cholinergic anti-inflammatory pathway and implications for therapy.

Authors:  J M Huston; K J Tracey
Journal:  J Intern Med       Date:  2011-01       Impact factor: 8.989

7.  Mixed-species biofilm compromises wound healing by disrupting epidermal barrier function.

Authors:  Sashwati Roy; Haytham Elgharably; Mithun Sinha; Kasturi Ganesh; Sarah Chaney; Ethan Mann; Christina Miller; Savita Khanna; Valerie K Bergdall; Heather M Powell; Charles H Cook; Gayle M Gordillo; Daniel J Wozniak; Chandan K Sen
Journal:  J Pathol       Date:  2014-05-27       Impact factor: 7.996

8.  Staphylococcus aureus Biofilm Infection Compromises Wound Healing by Causing Deficiencies in Granulation Tissue Collagen.

Authors:  Sashwati Roy; Suman Santra; Amitava Das; Sriteja Dixith; Mithun Sinha; Subhadip Ghatak; Nandini Ghosh; Pradipta Banerjee; Savita Khanna; Shomita Mathew-Steiner; Piya Das Ghatak; Britani N Blackstone; Heather M Powell; Valerie K Bergdall; Daniel J Wozniak; Chandan K Sen
Journal:  Ann Surg       Date:  2020-06       Impact factor: 13.787

9.  Diabetes induces fibrotic changes in the lung through the activation of TGF-β signaling pathways.

Authors:  Girish Talakatta; Mohsen Sarikhani; Jaseer Muhamed; K Dhanya; Bagganahalli S Somashekar; Padukudru Anand Mahesh; Nagalingam Sundaresan; P V Ravindra
Journal:  Sci Rep       Date:  2018-08-09       Impact factor: 4.379

10.  Novel mechanisms of Collagenase Santyl Ointment (CSO) in wound macrophage polarization and resolution of wound inflammation.

Authors:  Amitava Das; Soma Datta; Eric Roche; Scott Chaffee; Elizabeth Jose; Lei Shi; Komel Grover; Savita Khanna; Chandan K Sen; Sashwati Roy
Journal:  Sci Rep       Date:  2018-01-26       Impact factor: 4.379
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  1 in total

1.  Genome-wide DNA hypermethylation opposes healing in patients with chronic wounds by impairing epithelial-mesenchymal transition.

Authors:  Kanhaiya Singh; Yashika Rustagi; Ahmed S Abouhashem; Saba Tabasum; Priyanka Verma; Edward Hernandez; Durba Pal; Dolly K Khona; Sujit K Mohanty; Manishekhar Kumar; Rajneesh Srivastava; Poornachander R Guda; Sumit S Verma; Sanskruti Mahajan; Jackson A Killian; Logan A Walker; Subhadip Ghatak; Shomita S Mathew-Steiner; Kristen E Wanczyk; Sheng Liu; Jun Wan; Pearlly Yan; Ralf Bundschuh; Savita Khanna; Gayle M Gordillo; Michael P Murphy; Sashwati Roy; Chandan K Sen
Journal:  J Clin Invest       Date:  2022-09-01       Impact factor: 19.456
  1 in total

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