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Literature DB >> 340236

Effect of libexin combinatum (libexine and emetine) on phagocytosis by polymorphonuclear granulocytes and alveolar macrophages.

Abstract

The ability of human polymorphonuclear granulocytes and alveolar macrophages from rats to ingest Saccharomyces cerevisiae was tested in vitro in the presence of various concentrations of emetine and libexine. Emetine 4.0 and 40.0 microgram/ml caused an increase in the phagocytic index of polymorphonuclear granulocytes and alveolar macrophages. After oral administration of emetine the phagocytosis-enhancing effect was still apparent. Intracellular killing was not influenced by emetine or libexine.

Entities: Chemical Species

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Year: 1977 PMID： 340236 DOI： 10.1007/bf00562449

Source DB: PubMed Journal: Eur J Clin Pharmacol ISSN： 0031-6970 Impact factor: 2.953

13 in total

1. EMETINE IN TREATMENT OF SEVERE SEPTIC STATES.

Authors: P SYNEK; V SYNEK
Journal: Br Med J Date: 1964-06-13

2. Impairment of pulmonary bacterial defense mechanisms by immunosuppressive agents.

Authors: G L Huber; F M LaForce; R J Mason; A P Monaco
Journal: Surg Forum Date: 1970

3. Acquired phagocyte dysfunction. A complication of the hypophosphatemia of parenteral hyperalimentation.

Authors: P R Craddock; Y Yawata; L VanSanten; S Gilberstadt; S Silvis; H S Jacob
Journal: N Engl J Med Date: 1974-06-20 Impact factor: 91.245

4. Fungal septicemia in patients receiving parenteral hyperalimentation.

Authors: C R Curry; P G Quie
Journal: N Engl J Med Date: 1971-11 Impact factor: 91.245

Review 5. Effects of hyperosmolality on candidacidal activity of human neutrophil polymorphonuclear leukocytes and on clumping of Candida albicans by human serum.

Authors: S Kernbaum
Journal: Biomedicine Date: 1976-05

6. Enhancement of bactericidal capacity of alveolar macrophages by human alveolar lining material.

Authors: J A Juers; R M Rogers; J B McCurdy; W W Cook
Journal: J Clin Invest Date: 1976-08 Impact factor: 14.808

7. In vitro bactericidal capacity of human polymorphonuclear leukocytes: diminished activity in chronic granulomatous disease of childhood.

Authors: P G Quie; J G White; B Holmes; R A Good
Journal: J Clin Invest Date: 1967-04 Impact factor: 14.808

Effect of libexin combinatum (libexine and emetine) on phagocytosis by polymorphonuclear granulocytes and alveolar macrophages.

1. EMETINE IN TREATMENT OF SEVERE SEPTIC STATES.

2. Impairment of pulmonary bacterial defense mechanisms by immunosuppressive agents.

3. Acquired phagocyte dysfunction. A complication of the hypophosphatemia of parenteral hyperalimentation.

4. Fungal septicemia in patients receiving parenteral hyperalimentation.

Review 5. Effects of hyperosmolality on candidacidal activity of human neutrophil polymorphonuclear leukocytes and on clumping of Candida albicans by human serum.

6. Enhancement of bactericidal capacity of alveolar macrophages by human alveolar lining material.

7. In vitro bactericidal capacity of human polymorphonuclear leukocytes: diminished activity in chronic granulomatous disease of childhood.

8. Levamisole in advanced human breast cancer.

9. Alterations in the bactericidal ability of rabbit alveolar macrophages as a result of tumbling stress.

10. THE ROLE OF THE ALVEOLAR MACROPHAGE IN THE CLEARANCE OF BACTERIA FROM THE LUNG.

1. Stimulating effect of triiodothyronine on cell-mediated immunity.