Sammer Diab1,2, Shemy Carasso3,4, Mattan Arazi5, Leonid Sternik5,6, Ehud Raanani5,6, Erez Kachel1,2, Liza Grosman-Rimon1, Amjad Shalabi1, Offer Amir2,7,8. 1. Division of Cardiovascular Medicine and Surgery, Poriya Medical Center, Tiberias, Israel. 2. The Azrieli Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel. 3. Division of Cardiovascular Medicine and Surgery, Poriya Medical Center, Tiberias, Israel. shemy.carasso@gmail.com. 4. The Azrieli Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel. shemy.carasso@gmail.com. 5. Cardiac Surgery, Sheba Medical Center, Tel-Hashomer, Israel. 6. The Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. 7. Department of Cardiology, Hadassah Medical Center, Jerusalem, Israel. 8. Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Abstract
BACKGROUND: Management of patients treated with Ticagrelor is challenging, as stopping Ticagrelor prior to coronary bypass graft surgery (CABG) may increase the risk of acute stent thrombosis. The aim of the study was to compare bleeding complications in patients treated with ticagrelor combined with acetylsalicylic acid (ASA) versus ASA alone until 1 day before surgery. METHODS: Bleeding complications, defined as the composite of red blood cell transfusion ≥1000 ml, chest drainage ≥2000 ml, and bleeding requiring surgical re-exploration, were compared in 161 patients, with 101 on preoperative acetylsalicylic acid (ASA) alone (group A) and 65 on ticagrelor + ASA (group B). RESULTS: There were no differences in bleeding complications between the two groups (26% vs. 27% in group A and B, respectively), with similar chest drainage in the first 24 h (569 ± 393 ml and 649 ± 427 ml, respectively). CONCLUSIONS: Continuing ticagrelor until coronary artery bypass surgery was not associated with increased bleeding complications, suggesting that continued management with ticagrelor until surgery may be safe.
BACKGROUND: Management of patients treated with Ticagrelor is challenging, as stopping Ticagrelor prior to coronary bypass graft surgery (CABG) may increase the risk of acute stent thrombosis. The aim of the study was to compare bleeding complications in patients treated with ticagrelor combined with acetylsalicylic acid (ASA) versus ASA alone until 1 day before surgery. METHODS:Bleeding complications, defined as the composite of red blood cell transfusion ≥1000 ml, chest drainage ≥2000 ml, and bleeding requiring surgical re-exploration, were compared in 161 patients, with 101 on preoperative acetylsalicylic acid (ASA) alone (group A) and 65 on ticagrelor + ASA (group B). RESULTS: There were no differences in bleeding complications between the two groups (26% vs. 27% in group A and B, respectively), with similar chest drainage in the first 24 h (569 ± 393 ml and 649 ± 427 ml, respectively). CONCLUSIONS: Continuing ticagrelor until coronary artery bypass surgery was not associated with increased bleeding complications, suggesting that continued management with ticagrelor until surgery may be safe.
Authors: Christian W Hamm; Jean-Pierre Bassand; Stefan Agewall; Jeroen Bax; Eric Boersma; Hector Bueno; Pio Caso; Dariusz Dudek; Stephan Gielen; Kurt Huber; Magnus Ohman; Mark C Petrie; Frank Sonntag; Miguel Sousa Uva; Robert F Storey; William Wijns; Doron Zahger Journal: Eur Heart J Date: 2011-08-26 Impact factor: 29.983
Authors: Ezra A Amsterdam; Nanette K Wenger; Ralph G Brindis; Donald E Casey; Theodore G Ganiats; David R Holmes; Allan S Jaffe; Hani Jneid; Rosemary F Kelly; Michael C Kontos; Glenn N Levine; Philip R Liebson; Debabrata Mukherjee; Eric D Peterson; Marc S Sabatine; Richard W Smalling; Susan J Zieman Journal: J Am Coll Cardiol Date: 2014-09-23 Impact factor: 24.094
Authors: Emma C Hansson; Helena Rexius; Mikael Dellborg; Per Albertsson; Anders Jeppsson Journal: Eur J Cardiothorac Surg Date: 2014-01-30 Impact factor: 4.191
Authors: James J DiNicolantonio; Fabrizio D'Ascenzo; Ales Tomek; Saurav Chatterjee; Asfandyar K Niazi; Giuseppe Biondi-Zoccai Journal: Int J Cardiol Date: 2013-07-29 Impact factor: 4.164
Authors: Dominick J Angiolillo; Michael S Firstenberg; Matthew J Price; Pradyumna E Tummala; Martin Hutyra; Ian J Welsby; Michele D Voeltz; Harish Chandna; Chandrashekhar Ramaiah; Miroslav Brtko; Louis Cannon; Cornelius Dyke; Tiepu Liu; Gilles Montalescot; Steven V Manoukian; Jayne Prats; Eric J Topol Journal: JAMA Date: 2012-01-18 Impact factor: 56.272
Authors: Chantal L I Gielen; Eline F Bruggemans; Theo Stijnen; Jeroen Eikenboom; Giuseppe Tavilla; Anneke Brand; Robert J M Klautz Journal: Eur J Cardiothorac Surg Date: 2015-08-06 Impact factor: 4.191
Authors: Marco Roffi; Carlo Patrono; Jean-Philippe Collet; Christian Mueller; Marco Valgimigli; Felicita Andreotti; Jeroen J Bax; Michael A Borger; Carlos Brotons; Derek P Chew; Baris Gencer; Gerd Hasenfuss; Keld Kjeldsen; Patrizio Lancellotti; Ulf Landmesser; Julinda Mehilli; Debabrata Mukherjee; Robert F Storey; Stephan Windecker Journal: Eur Heart J Date: 2015-08-29 Impact factor: 29.983
Authors: Marijana Matejic-Spasic; Kambiz Hassan; Matthias Thielmann; Stephan Geidel; Robert F Storey; Michael Schmoeckel; Harriet Adamson; Efthymios N Deliargyris; Daniel Wendt Journal: J Thorac Dis Date: 2022-08 Impact factor: 3.005