Ali Pouryousef1, Erfan Eslami1, Sepehr Shahriarirad2, Sina Zoghi2, Mehdi Emami2, Mohammad Reza Cheraghi2, Bardia Zamiri2, Soliman Mohammadi-Samanii3, Bahador Sarkari4,5. 1. Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. 2. Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. 3. School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. 4. Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. sarkarib@sums.ac.ir. 5. Basic Sciences in Infectious Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. sarkarib@sums.ac.ir.
Abstract
OBJECTIVES: The current study aimed to evaluate the effects of Ficus carica latex on the treatment of cutaneous leishmaniasis (CL), induced by Leishmania major. A 5% topical gel with F. carica latex was prepared. BALB/c mice were infected by inoculation of amastigotes form of L. major. Thirty BALB/c mice were divided into five groups, where the first group was treated daily, the second group twice per day, and the third group every other day with the 5% topical gel, for 3 weeks. The sizes of the lesions were measured before and during the course of treatment. RESULTS: Although the mean size of lesions in the mice group treated with the 5% F. carica gel, especially in the group receiving daily treatment, was less than the mean size of the lesions in the control group, yet, the differences was not statistically significant (p > 0.05). The findings of the current study demonstrated that the 5% F. carica latex with a 3-week course of treatment had no considerable effect in recovery or control of CL induced by L. major in the murine model. Using higher concentration of F. carica latex and with longer treatment lengths may increase its efficacy in the treatment of CL.
OBJECTIVES: The current study aimed to evaluate the effects of Ficus carica latex on the treatment of cutaneous leishmaniasis (CL), induced by Leishmania major. A 5% topical gel with F. caricalatex was prepared. BALB/c mice were infected by inoculation of amastigotes form of L. major. Thirty BALB/c mice were divided into five groups, where the first group was treated daily, the second group twice per day, and the third group every other day with the 5% topical gel, for 3 weeks. The sizes of the lesions were measured before and during the course of treatment. RESULTS: Although the mean size of lesions in the mice group treated with the 5% F. carica gel, especially in the group receiving daily treatment, was less than the mean size of the lesions in the control group, yet, the differences was not statistically significant (p > 0.05). The findings of the current study demonstrated that the 5% F. caricalatex with a 3-week course of treatment had no considerable effect in recovery or control of CL induced by L. major in the murine model. Using higher concentration of F. caricalatex and with longer treatment lengths may increase its efficacy in the treatment of CL.
Entities:
Keywords:
Cutaneous leishmaniasis; Ficus carica; Latex; Leishmania major
Authors: B Pourmohammadi; M H Motazedian; F Handjani; G H R Hatam; S Habibi; B Sarkari Journal: Southeast Asian J Trop Med Public Health Date: 2011-05 Impact factor: 0.267
Authors: S A Hashemi; S Abediankenari; M Ghasemi; M Azadbakht; Y Yousefzadeh; A A Dehpour Journal: Iran Red Crescent Med J Date: 2011-04-01 Impact factor: 0.611