P Bazal1,2, A Gea1,3, A M Navarro1,2, J Salas-Salvadó3,4, D Corella3,5, A Alonso-Gómez3,6, M Fitó3,7, C Muñoz-Bravo8, R Estruch3,9, M Fiol3,10, J Lapetra3,11, L Serra-Majem3,12, E Ros3,13, J Rekondo3,6, M A Muñoz14,15, J Basora4, J V Sorlí3,5, E Toledo1,3, M A Martínez-González1,3,16, M Ruiz-Canela1,3. 1. Department of Preventive Medicine and Public Health, University of Navarra, Spain. 2. Servicio Navarro de Salud-Osasunbidea, Spain. 3. CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Spain. 4. Departament de Bioquímica i Biotecnologia, Universitat Rovira i Virgili, Unitat de Nutriciœ Humana, Hospital Universitari San Joan de Reus, Institut d'Investigació Pere Virgili (IISPV), Spain. 5. Department of Preventive Medicine, University of Valencia, Spain. 6. Department of Cardiology, University Hospital Araba, Spain. 7. Cardiovascular Risk and Nutrition (Regicor Study Group), Hospital del Mar Medical Research Institute (IMIM), Spain. 8. Department of Public Health, University of Malaga, Spain. 9. Department of Internal Medicine, Institut d'Investigacions Biomèdiques, August Pi i Sunyer Hospital Clinic, University of Barcelona, Spain. 10. Illes Balears Health Research Institute (IdISBa), Spain. 11. Department of Family Medicine, Research Unit, Distrito Sanitario Atención Primaria de Sevilla, Spain. 12. Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria and CHUIMI Canarian Health Service, Spain. 13. Endocrinology and Nutrition Service, Institut d'Investigacions Biomèdiques August Pi Sunyer, Hospital Clinic, Spain. 14. Gerència Territorial de Barcelona, Institut Català de la Salut, Spain. 15. Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Spain. 16. Department of Nutrition, Harvard TH Chan School of Public Health, USA.
Abstract
AIMS: The association between caffeinated coffee consumption and atrial fibrillation remains unclear. Recent studies suggest an inverse association only between a moderate caffeinated coffee consumption and atrial fibrillation, but others have reported no association. The aim of our study was to prospectively assess the association between caffeinated coffee consumption and atrial fibrillation in two Spanish cohorts, one of adults from a general population and another of elderly participants at high cardiovascular risk. METHODS AND RESULTS: We included 18,983 and 6479 participants from the 'Seguimiento Universidad de Navarra' (SUN) and 'Prevención con Dieta Mediterránea' (PREDIMED) cohorts, respectively. Participants were classified according to their caffeinated coffee consumption in three groups: ≤3 cups/month, 1-7 cups/week, and >1 cup/day. We identified 97 atrial fibrillation cases after a median follow-up of 10.3 years (interquartile range 6.5-13.5), in the SUN cohort and 250 cases after 4.4 years median follow-up (interquartile range 2.8-5.8) in the PREDIMED study. No significant associations were observed in the SUN cohort although a J-shaped association was suggested. A significant inverse association between the intermediate category of caffeinated coffee consumption (1-7 cups/week) and atrial fibrillation was observed in PREDIMED participants with a multivariable-adjusted hazard ratio = 0.53 (95% confidence interval 0.36-0.79) when compared with participants who did not consume caffeinated coffee or did it only occasionally. No association was found for higher levels of caffeinated coffee consumption (>1 cup per day), hazard ratio = 0.79 (95% confidence interval 0.49-1.28). In the meta-analysis of both PREDIMED and SUN studies, the hazard ratio for intermediate consumption of caffeinated coffee was 0.60 (95% confidence interval 0.44-0.82) without evidence of heterogeneity. Similar findings were found for the association between caffeine intake and atrial fibrillation risk. CONCLUSION: Intermediate levels of caffeinated coffee consumption (1-7 cups/week) were associated with a reduction in atrial fibrillation risk in two prospective Mediterranean cohorts. Published on behalf of the European Society of Cardiology. All rights reserved.
AIMS: The association between caffeinated coffee consumption and atrial fibrillation remains unclear. Recent studies suggest an inverse association only between a moderate caffeinated coffee consumption and atrial fibrillation, but others have reported no association. The aim of our study was to prospectively assess the association between caffeinated coffee consumption and atrial fibrillation in two Spanish cohorts, one of adults from a general population and another of elderly participants at high cardiovascular risk. METHODS AND RESULTS: We included 18,983 and 6479 participants from the 'Seguimiento Universidad de Navarra' (SUN) and 'Prevención con Dieta Mediterránea' (PREDIMED) cohorts, respectively. Participants were classified according to their caffeinated coffee consumption in three groups: ≤3 cups/month, 1-7 cups/week, and >1 cup/day. We identified 97 atrial fibrillation cases after a median follow-up of 10.3 years (interquartile range 6.5-13.5), in the SUN cohort and 250 cases after 4.4 years median follow-up (interquartile range 2.8-5.8) in the PREDIMED study. No significant associations were observed in the SUN cohort although a J-shaped association was suggested. A significant inverse association between the intermediate category of caffeinated coffee consumption (1-7 cups/week) and atrial fibrillation was observed in PREDIMED participants with a multivariable-adjusted hazard ratio = 0.53 (95% confidence interval 0.36-0.79) when compared with participants who did not consume caffeinated coffee or did it only occasionally. No association was found for higher levels of caffeinated coffee consumption (>1 cup per day), hazard ratio = 0.79 (95% confidence interval 0.49-1.28). In the meta-analysis of both PREDIMED and SUN studies, the hazard ratio for intermediate consumption of caffeinated coffee was 0.60 (95% confidence interval 0.44-0.82) without evidence of heterogeneity. Similar findings were found for the association between caffeine intake and atrial fibrillation risk. CONCLUSION: Intermediate levels of caffeinated coffee consumption (1-7 cups/week) were associated with a reduction in atrial fibrillation risk in two prospective Mediterranean cohorts. Published on behalf of the European Society of Cardiology. All rights reserved.
Authors: Yalin Cao; Xiao Liu; Zhengbiao Xue; Kang Yin; Jianyong Ma; Wengen Zhu; Fuwei Liu; Jun Luo; Junyi Sun Journal: Front Cardiovasc Med Date: 2022-07-06
Authors: Leticia Goni; Víctor de la O; M Teresa Barrio-López; Pablo Ramos; Luis Tercedor; Jose Luis Ibañez-Criado; Eduardo Castellanos; Alicia Ibañez Criado; Rosa Macias Ruiz; Ignacio García-Bolao; Jesus Almendral; Miguel Ángel Martínez-González; Miguel Ruiz-Canela Journal: J Med Internet Res Date: 2020-12-07 Impact factor: 5.428