| Literature DB >> 34021266 |
Manli Liu1, Zhongyi Wan1, Sumei Yang2, Fang Liu1, Xiliang Yang2, Zhaoyuan Wu1, Yanni Zhang1, Kaimei Wang1, Wei Fang3.
Abstract
Two new dipimprinine alkaloids dipimprinine E (1) and dipimprinine F (2) were isolated from Streptomyces sp. 44414B. The structure was elucidated by extensive spectroscopic analysis, including ESI-MS, HR-MS, and 1D and 2D NMR experiments. Dipimprinines F (2) showed cytotoxic activities against three tumor cell lines, including A-875, Hep G2, and H-460, with IC50 values of 26.4, 0.5, and 9.0 μg ml-1, respectively.Entities:
Year: 2021 PMID： 34021266 DOI： 10.1038/s41429-021-00424-3
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649