Ania K Dabrowski1, Melisa Carrasco2, John R Gatti3, Andre R F Barreto4, Charlamaine Parkinson5, Shenandoah Robinson6, Aylin Tekes7, Lisa R Sun8. 1. Department of Neurology, The Johns Hopkins School of Medicine, Baltimore, Maryland; Neurosciences Intensive Care Nursery, Johns Hopkins School of Medicine, Baltimore, Maryland. 2. Department of Neurology, The Johns Hopkins School of Medicine, Baltimore, Maryland; Neurosciences Intensive Care Nursery, Johns Hopkins School of Medicine, Baltimore, Maryland; Department of Neurology, University of Michigan School of Medicine, Ann Arbor, Michigan. 3. The Johns Hopkins School of Medicine, Baltimore, Maryland. 4. Division of Pediatric Radiology and Pediatric Neuroradiology, Russell Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland. 5. Neurosciences Intensive Care Nursery, Johns Hopkins School of Medicine, Baltimore, Maryland; Division of Neonatology, Department of Pediatrics, The Johns Hopkins School of Medicine, Baltimore, Maryland. 6. Department of Neurology, The Johns Hopkins School of Medicine, Baltimore, Maryland; Neurosciences Intensive Care Nursery, Johns Hopkins School of Medicine, Baltimore, Maryland; Department of Neurosurgery, The Johns Hopkins School of Medicine, Baltimore, Maryland. 7. Neurosciences Intensive Care Nursery, Johns Hopkins School of Medicine, Baltimore, Maryland; Division of Pediatric Radiology and Pediatric Neuroradiology, Russell Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland. 8. Department of Neurology, The Johns Hopkins School of Medicine, Baltimore, Maryland; Neurosciences Intensive Care Nursery, Johns Hopkins School of Medicine, Baltimore, Maryland. Electronic address: Lsun20@jhmi.edu.
Abstract
BACKGROUND: Subpial hemorrhages are underrecognized, underreported, and poorly understood. The spectrum of their clinical manifestations and consequences in neonates has not been fully described. Here, we describe the demographic, clinical, and radiographic characteristics of neonates with subpial hemorrhages. METHODS: We reviewed the medical records and neuroimaging studies of neonates with subpial hemorrhage who were admitted to our neonatal intensive care unit between September 2009 and December 2020. RESULTS: Of 114 neonates with intracranial hemorrhage, 31 (27%) had subpial hemorrhage. The majority of neonates in our cohort were male (68%) and born at term (55%). The most common imaging indication was apneas and/or seizures in 58%. Common comorbid conditions included cardiorespiratory failure (42%), hypoxic-ischemic encephalopathy (26%), and coagulopathy (23%). Subpial hemorrhages were multifocal in 45% of neonates, located in the temporal lobe in 45% of neonates, and tended to be larger in neonates with coagulopathy, birth trauma, or hydrocephalus requiring neurosurgical intervention. Subpial hemorrhage was associated with another type of intracranial bleed in 77% of cases and with arterial ischemic stroke in 16% of cases. Of 17 patients with more than one year of follow-up data, 14 (82%) have developmental delay and four (24%) have epilepsy. Of 14 patients with follow-up imaging, 10 (71%) had encephalomalacia subjacent to the subpial hemorrhage. CONCLUSIONS: This is the largest cohort of neonates with subpial hemorrhages to date. Outcome data are limited by duration of follow-up and may be confounded by comorbid conditions and other concurrent hemorrhages. Further study is needed to define the spectrum of risk factors and expected neurological outcomes.
BACKGROUND: Subpial hemorrhages are underrecognized, underreported, and poorly understood. The spectrum of their clinical manifestations and consequences in neonates has not been fully described. Here, we describe the demographic, clinical, and radiographic characteristics of neonates with subpial hemorrhages. METHODS: We reviewed the medical records and neuroimaging studies of neonates with subpial hemorrhage who were admitted to our neonatal intensive care unit between September 2009 and December 2020. RESULTS: Of 114 neonates with intracranial hemorrhage, 31 (27%) had subpial hemorrhage. The majority of neonates in our cohort were male (68%) and born at term (55%). The most common imaging indication was apneas and/or seizures in 58%. Common comorbid conditions included cardiorespiratory failure (42%), hypoxic-ischemic encephalopathy (26%), and coagulopathy (23%). Subpial hemorrhages were multifocal in 45% of neonates, located in the temporal lobe in 45% of neonates, and tended to be larger in neonates with coagulopathy, birth trauma, or hydrocephalus requiring neurosurgical intervention. Subpial hemorrhage was associated with another type of intracranial bleed in 77% of cases and with arterial ischemic stroke in 16% of cases. Of 17 patients with more than one year of follow-up data, 14 (82%) have developmental delay and four (24%) have epilepsy. Of 14 patients with follow-up imaging, 10 (71%) had encephalomalacia subjacent to the subpial hemorrhage. CONCLUSIONS: This is the largest cohort of neonates with subpial hemorrhages to date. Outcome data are limited by duration of follow-up and may be confounded by comorbid conditions and other concurrent hemorrhages. Further study is needed to define the spectrum of risk factors and expected neurological outcomes.