| Literature DB >> 34019843 |
Abstract
SMAD4 mutations that disrupt its interaction with SMAD3 and attenuate tumor suppression by TGF-β are major oncogenic drivers. Tang et al. (2020) report the discovery of small molecules that restore the SMAD4:SMAD3 complex and its cytostatic activity, exemplifying the therapeutic potential of fixing tumor suppressor mutants using molecular glues.Entities:
Year: 2021 PMID： 34019843 DOI： 10.1016/j.chembiol.2021.04.023
Source DB: PubMed Journal: Cell Chem Biol ISSN： 2451-9448 Impact factor: 8.116