| Literature DB >> 34019293 |
Hsin-Yao Tang1, Aaron R Goldman2, Xue Zhang2,3, David W Speicher2, Chi V Dang4,5.
Abstract
The MYC gene regulates normal cell growth and is deregulated in many human cancers, contributing to tumor growth and progression. The MYC transcription factor activates RNA polymerases I, II, and III target genes that are considered housekeeping genes. These target genes are largely involved in ribosome biogenesis, fatty acid, protein and nucleotide synthesis, nutrient influx or metabolic waste efflux, glycolysis, and glutamine metabolism. MYC's function as a driver of cell growth has been revealed through RNA sequencing, genome-wide chromatin immunoprecipitation, proteomics, and importantly metabolomics, which is highlighted in this chapter.Entities:
Keywords: Cancer metabolism; MYC; Mass spectrometry; Metabolomics; Transcription
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Year: 2021 PMID： 34019293 PMCID： PMC8417761 DOI： 10.1007/978-1-0716-1476-1_11
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745