| Literature DB >> 3401745 |
M J During1, I N Acworth, R J Wurtman.
Abstract
Intracerebral dialysis was used to monitor extracellular fluid from rat striatum and nucleus accumbens following the intraperitoneal administration of tyrosine. Dopamine concentrations in dialysates from both the striatum and the nucleus accumbens increased significantly in response to the tyrosine. The magnitude of the tyrosine effect was greater in the nucleus accumbens than in the striatum. Hence, mesolimbic dopaminergic neurons may be especially responsive to precursor availability.Entities:
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Year: 1988 PMID： 3401745 DOI： 10.1016/0006-8993(88)90043-1
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252