Outcomes in Patients with pT3N0M0 Breast Cancer with and without Postmastectomy Radiotherapy.

PURPOSE: The role of adjuvant postmastectomy radiotherapy (PMRT) remains controversial for patients with pT3N0M0 breast cancer, especially when patients are treated with the updated adjuvant chemotherapy. Our study aimed to compare locoregional recurrence-free survival (LRFS), disease-free survival (DFS), and breast cancer-specific survival (BCSS) in pT3N0M0 patients with and without postmastectomy radiotherapy. PATIENTS AND METHODS: Between October 2000 and 8 September 2016, the database of the Breast Cancer Center of Shanghai yielded 114 patients with node-negative non-metastatic breast cancer larger than 5 cm. Univariate and multivariate analyses were performed to assess the risk factors for survivals. Differences between the two groups were compared using the Log rank test.
RESULTS: Fifty-nine (51.8%) of the patients received adjuvant PMRT. The median follow-up was 62.3 months. Five-year LRFS was 100% in the PMRT group vs 98.1% in the non-PMRT group (P=0.17); 5-year DFS was 97.1% for the entire cohort, 98.0% for the PMRT group vs 96.2% for the non-PMRT group (P=0.18). Univariate analysis identified that family history of malignant tumors, lymphovascular invasion (LVI), or triple-negative breast cancer (TNBC) molecular subtype were associated with higher locoregional recurrence (LRR) (P<0.05). No PMRT was the only risk factor independently associated with poorer DFS (P=0.048) on multivariate analysis. No difference in BCSS was observed between the two groups.
CONCLUSION: The present study demonstrated a low LRR rate and good survival for node-negative breast cancer >5 cm. Patients with family history of malignant tumors, TNBC subtype, LVI positivity, or grade 3 disease are at high risk for LRR and might benefit from PMRT.

Plain Language Summary

It is confusing for both doctors and node-negative non-metastatic breast cancer patients with tumors of 5 cm or larger to decide whether to receive post-operation radiotherapy. Therefore, we did this research, and our team report that pT3N0M0 breast cancer patients generally had a good prognosis. Patients with high-risk factors such as triple-negative breast cancer subtype, malignant tumor diagnosis among the first- and second-degree relatives, pathological results indicating lymphovascular invasion or high-grade disease should consider postmastectomy radiotherapy (PMRT).

Introduction

Breast cancer is the most commonly diagnosed malignancy in women and the most commonly diagnosed cancer worldwide.1 However, pT3N0M0 breast cancer is rare, representing <1% of new breast cancer cases.2 According to the National Comprehensive Cancer Network (NCCN) guidelines for breast cancer, patients with positive lymph nodes after mastectomy were routinely recommended to undergo radiation therapy, but for those with negative lymph nodes, the indication of PMRT is still controversial, especially for pT3 disease.3

In 2005, the Early Breast Cancer Trialists’ Collaborative Group (EBCTCG) demonstrated a reduced 5-year local recurrence rate (LRR) (6% to 2%) for node-negative patients who underwent PMRT, along with increased non-breast cancer mortality,4 while the radiotherapy techniques applied in the EBCTCG analysis were outdated and the database of patients included node-negative patients with pT1–2 and pT4.

Though without unanimous recommendations, the number of pT3N0M0 patients receiving PMRT is increasing over time,5 from 22% reported between 1998–20025 to 42% between 2000–2010,6 and the percent is even higher for younger patients (47% for those aged <50 years from 1998–2007).7 Recent studies demonstrated nearly half of patients with pT3N0M0 diagnosis received PMRT.8,9 The MD Anderson Cancer Center indicated that 73.5% of cT3N0 and 64.0% of pT3N0M0 patients received PMRT.10

Considering the cost and side effects of PMRT, it is important to define the role of PMRT for the pT3N0M0 subgroup in this new era of radiotherapy and identify those who can really benefit from PMRT in this setting. Many studies explored the role of PMRT in breast cancer patients with a pathologic diagnosis of pT3N0M0, but the results were conflicting. Hence, we reviewed pT3N0M0 patients in our breast cancer center treated with updated adjuvant chemotherapy. Our study is one of the studies with large sample size regarding pT3N0M0 breast cancer patients, and will help to optimize the treatment strategies for this special group of patients in the new era.

Patients and Methods

Patients

From January 2000 to September 2016, 30,099 breast cancer patients were treated in our institute, 253 (0.84%) patients were staged as T3N0M0, a total of 114 female patients with primary breast cancer diagnosed as pT3N0M0 were retrospectively reviewed in our study. All patients were treated with modified mastectomy with or without adjuvant therapy, including chemotherapy, hormonal therapy, and PMRT. Patients with a malignant cancer diagnosis before, or with bilateral breast cancer at diagnosis, or who received neoadjuvant chemotherapy, and those with a follow-up time of less than 4 months were excluded. A positive family history was defined as having malignant tumor among the first- and second-degree relatives. The review of data for this investigation was approved by the Ethic Committee Office of Fudan University Shanghai Cancer Center.

Treatments

Among patients who underwent PMRT, 4 patients received two-dimensional radiotherapy (2DRT), 27 patients received three-dimensional conformal radiotherapy (3D-CRT), 22 patients received intensity modulated radiotherapy (IMRT), 6 patients received PMRT but without radiation technique information. When PMRT was used, a dose of 50 Gy in 25 fractions was delivered to the chest wall without regional nodal basins.

Statistical Analysis

Locoregional recurrence (LRR) was defined as disease recurrence in the ipsilateral chest wall or the ipsilateral regional lymph nodal basins (axilla, internal mammary lymph node, supraclavicular fossa, or infraclavicular fossa). Distant metastasis (DM) was defined as disease recurrence other than at LRR sites. Disease-free survival (DFS) was defined as living without any LRR or DM events. Time to locoregional free survival (LRFS), DFS, and breast cancer-specific survival (BCSS) were calculated from the date of pathology diagnosis. The clinicopathological characteristics between two groups were compared using Pearson’s Chi-square test or Fisher exact test. Cox proportional hazards models are used to identify prognostic factors of LRFS and DFS. Variables with a P-value less than 0.2 in univariate analysis and those reported as important in previous studies were included in multivariate analysis. Survivals were calculated by the Kaplan-Meier method and comparisons were performed using the Log rank test. Because there was a low rate of LRR (2/114, 1.75%), multivariate analysis was not performed for LRFS. The distribution of factors between groups was analyzed using the chi-squared method. P-values of less than 0.05 were considered statistically significant. Statistical analyses were performed using R package 3.6.2 ().

Results

Patient and Tumor Characteristics

The median follow-up time of patients was 62.3 (range, 4.6–211.7) months for the entire cohort, 61.9 months for the PMRT cohort, and 62.7 months for the non-PMRT cohort. Totally, 80.7% of patients received adjuvant chemotherapy. The majority (73/92, 79.35%) of the patients received anthracycline-based chemotherapy, with approximately half (47/92, 51.1%) of the patients receiving a combination of anthracycline and taxane, while 13% (12/92) of the patients received taxane-based chemotherapy only. A small group (7/92, 7.61%) of patients received chemotherapies other than those mentioned above, with five of seven undergoing CMF (cyclophosphamide, methotrexate, 5-fluorouracil) treatment. Complete axillary lymph node dissection was performed in 95 (83.3%) patients, while sentinel lymph node biopsy was performed in 19 (16.7%) patients. The median number of lymph nodes dissected during surgery was 15. In total, 85.0% (51/60) of ER/PR positive patients received hormonal therapy with either tamoxifen or an aromatase inhibitor, while 56.8% (21/37) of patients who were HER2-positive were treated with trastuzumab. Clinical and pathological characteristics of the patients are listed in Table 1.

Table 1

Patients’ Characteristics

Characteristics	All Patients (n = 114)		PMRT (n = 59)		No PMRT (n = 55)		P value
	No.	%	No.	%	No.	%
Age (years)
Median (range)	53 (26–80)		50 (26–80)		57 (28–78)
<50	41	35.96	29	49.2	12	21.8	0.002
≥50	73	64.04	30	50.8	43	78.2
Family history
Negative	99	86.8	51	86.4	48	87.3	0.896
Positive	15	13.16	8	13.6	7	12.7
Menstrual status
Premenopausal	49	42.98	30	50.8	19	34.5	0.079
Postmenopausal	65	57.02	29	49.2	36	65.5
Pathology
IDC	94	82.46	52	88.1	42	76.4	0.099
Other	20	17.54	7	11.9	13	23.6
Tumor size (cm)
Median (range)	6.0 (5.1–16.0)		6.0 (5.1–12.0)		6.0 (5.1–16.0)		0.383
5.1–7.0	43	37.72	20	33.9	23	41.8
>7.0	71	62.28	39	66.1	32	58.2
Grade
I–II	58	50.88	32	54.24	26	47.27	0.968
III	42	36.84	23	38.98	19	34.55
Unknown	14	12.28	4	6.78	10	18.18
ALND
≤15	58	50.9	27	45.8	31	56.4	0.258
>15	56	49.1	32	54.2	24	43.6
ER
Negative	46	40.4	22	37.3	24	43.6	0.432
Positive	65	57.0	36	61.0	29	52.7
Unknown	3	2.63	1	1.69	2	3.64
PR
Negative	59	51.8	31	52.5	28	50.9	0.948
Positive	52	45.6	27	45.8	25	45.5
Unknown	3	2.63	1	1.69	2	3.64
HER2
Negative	70	61.4	37	62.7	33	60.0	0.882
Positive	37	32.5	19	32.2	18	32.7
Unknown	7	6.14	3	5.08	4	7.27
Ki-67
≤15%	30	26.32	18	30.5	12	21.8	0.798
>15%	56	49.12	32	54.2	24	43.6
Unknown	28	24.56	9	15.3	19	34.5
Subtype
Non-TNBC	90	78.95	47	79.7	43	78.2	0.990
TNBC	21	18.42	11	18.6	10	18.2
Unknown	3	2.63	1	1.7	2	3.6
LVI
Negative	73	64.04	40	67.8	33	60.0	0.210
Positive	23	20.18	16	27.1	7	12.73
Unknown	18	15.8	3	5.08	15	27.27
Margin
Negative	113	99.12	58	98.3	55	100	1.00
Positive	1	0.88	1	1.7	0	0.00
Chemotherapy
No	19	16.7	6	10.2	13	23.6	0.071
Yes	92	80.7	50	84.7	42	76.4
Unknown	3	2.60	3	5.08	0	0
Herceptin in HER2+patients
No	16	43.2	9	47.4	7	38.9	0.603
Yes	21	56.8	10	52.6	11	61.1
HT in ER/PR+ patients
No	9	15.0	3	9.7	6	20.7	0.292
Yes	51	85.0	28	90.3	23	79.3

Abbreviations: PMRT, post-mastectomy radiotherapy; IDC, invasive ductal carcinoma; ALND, axillary lymph node dissection; ER, estrogen receptor; PR, progesterone receptor; HER2, human epithelial growth factor receptor-2; TNBC, triple-negative breast cancer; LVI, lymphovascular invasion; HT, hormonal therapy.

Of the 114 patients enrolled in the study, fifty-nine (59/114, 51.8%) patients received PMRT, while 55 (55/114, 48.2%) did not. One patient in the PMRT group had positive margins. Younger patients were more likely to be offered radiation (P=0.002), while other variables were balanced between the two groups. Approximately 61.2% of premenopausal patients received PMRT (P=0.079), and more patients in the PMRT group had lymphovascular invasion (LVI) (27.1% vs 12.73%, P=0.210) or received adjuvant chemotherapy (84.7% vs 76.4%, P=0.071) compared with the non-PMRT group. The use of PMRT across different years showed a relatively stable trend after 2010, about 50% of pT3N0M0 patients underwent PMRT.

LRR According to PMRT Use

The 5-year cumulative LRFS was 98.1% in the non-PMRT cohort and 100% in the PMRT cohort. The cumulative survival of LRFS is plotted in Figure 1 according to PMRT use. PMRT tended to improve LRFS for pT3N0M0 patients but did not reach statistical significance (P=0.17). Two LRR events occurred, both of which were in the non-PMRT cohort. Both events occurred in patients with triple-negative breast cancer (TNBC) molecular subtype, grade 3 pathologic features, and LVI positivity. One of the patients experienced relapse in the regional axillary lymph nodes 10 months after mastectomy, without simultaneous distant failure. This patient had a total of 10 lymph nodes removed at axillary dissection and had a relatively bigger tumor of 12 cm in diameter and received taxane-based chemotherapy without PMRT. The second patient had LRR in the chest wall and subclavicular lymph nodes with simultaneous distant failure in bone, pleura, and mediastinal lymph nodes 8 years after primary surgery. This patient had 20 lymph nodes removed at axillary dissection and received adjuvant chemotherapy without PMRT. Both patients were alive at the last follow-up. No LRR event was observed after distant metastasis. We did not identify any events in the only patient in the PMRT group that had positive margins.

Figure 1

LRFS of patients with pT3N0M0 breast cancer according to PMRT.

We performed a univariate analysis on LRFS (Table 2). Patients with a family history of malignant tumors had a poorer LRFS (P=0.0078). TNBC patients were at risk of higher LRR than non-TNBC patients, regardless of whether we defined HER2 ++ (immunohistochemical staining) as negative (P=0.0062) or positive (P=0.0014). Furthermore, if we divided patients into three subtypes, patients with luminal or HER2-positive subtypes had better LRFS than TNBC patients (P=0.023 and P=0.035; respectively). ER positivity seemed to be a protective factor for LRFS in pT3N0M0 patients (P=0.059). The univariate analysis showed grade 3 histologic features (P=0.078) and LVI positivity (P=0.0039) were unfavorable prognostic factors for LRFS. Because of the rarity of LRR events, multivariate analysis was not performed for LRFS.

Table 2

Local-Recurrence Rate and Univariate Analysis of LRFS

Variables	LRR % (Events/No. of Patients)	P value
Family history		0.0078
Negative	1.01 (1/99)
Positive	6.67 (1/15)
ER status		0.0593
Negative	4.35 (2/46)
Positive	0.00 (0/65)
Subtype		0.0062
TNBC	9.52 (2/21)
Non-TNBC	0.00 (0/90)
Subtype (HER2++ as positive)		0.0014
TNBC	10.5 (2/19)
Non-TNBC	0.00 (0/92)
Subtype		0.0235
TNBC	9.52 (2/21)
HER2+	0.00 (0/24)
Luminal	0.00 (0/66)
PMRT		0.1701
No	3.64 (2/55)
Yes	0.00 (0/59)
Grade		0.0776
I–II	0.00 (0/58)
III	4.76 (2/42)
LVI		0.0039
Negative	0.00 (0/73)
Positive	8.70 (2/23)

Abbreviations: LRR, local-recurrence rate; ER, estrogen receptor; TNBC, triple-negative breast cancer; HER2, human epithelial growth factor receptor-2; PMRT, post-mastectomy radiotherapy; LVI, lymphovascular invasion.

DFS According to PMRT Use

Five-year DFS was 96.2% in the non-PMRT cohort, and 98.0% in the PMRT cohort (P=0.18). Among the 5 patients who had events during follow-up, two patients had LRR, and four patients developed distant metastasis (three in the non-PMRT group and one in the PMRT group). The only distant metastasis in PMRT group occurred in bone at 40.7 months after primary surgery and this patient was 30 years old at diagnosis with luminal subtype, had a total of 22 lymph nodes removed at axillary dissection, and finally died of breast cancer 2 years later. She received hormonal therapy and adjuvant chemotherapy based on anthracycline and taxane. Among the three patients with distant metastasis in the non-PMRT cohort, one had simultaneous LRR and has been described before, and the other two patients both suffered lung metastasis, with one having mediastinal lymph node involvement. A total of 17 and 18 lymph nodes were removed at axillary dissection in the two patients with lung metastasis. The patient who developed DM 12.1 months after primary surgery died of breast cancer approximately 2 years later, while the other patient who developed DM 8.3 years after primary surgery was still alive at last follow-up. Both patients received hormonal therapy and adjuvant chemotherapy based on anthracycline and taxane. The former had grade 3 histological features and was HER2-positive, undergoing two cycles of trastuzumab treatment.

We performed univariate (P=0.18; Figure 2A) and multivariate (P=0.048; Figure 2B) analysis of DFS with factors reported to be important in the clinical setting (Table 3), and identified PMRT as the only independent favorable factor in DFS.

Figure 2

DFS according to PMRT use. (A) DFS from univariate analysis. (B) Co-adjusted curves of DFS from multivariate analysis.

Table 3

Univariate and Multivariate Analysis of DFS

Variables	Disease Progression% (Events/No. of Patients)	Univariate Analysis	Multivariate Analysis
		P value	P value	HR
Family history		0.024	0.2533	7.57403
Negative	9.09 (9/99)
Positive	20.0 (3/15)
Menstrual status		0.61	0.6351	2.32795
Premenopausal	8.16 (4/49)
Postmenopausal	12.3 (8/65)
Age		1.0	0.9111	1.18348
≥50	11.0 (8/73)
<50	9.76 (4/41)
Tumor size (cm)		0.57	0.1780	8.66409
5.1–7	5/43 (11.6)
>7	7/71 (9.86)
Grade		0.42	0.3561	0.26012
I–II	8/58 (13.8)
III	3/42 (7.14)
LVI		0.97	0.9332	0.90240
Negative	7/73 (9.59)
Positive	2/23 (8.70)
ALND		0.35	0.1834	0.15988
>15	7/56 (12.5)
≤15	5/58 (8.62)
Subtype		0.8	0.1405	29.82472
TNBC	2/19 (10.5)
Non-TNBC	9/92 (9.78)
ER status		0.6	0.4286	12.44894
Positive	6/65 (9.23)
Negative	5/46 (10.9)
PR status		0.27	0.3125	0.03505
Positive	4/52 (7.69)
Negative	7/59 (11.9)
HER2 status		0.75	0.4763	3.46134
Negative	8/74 (10.8)
Positive	3/37 (8.10)
PMRT		0.38	0.0485	15.77801
No	4/59 (6.78)
Yes	8/55 (14.5)

Abbreviations: LRR, local-recurrence rate; HR, hazard ratio; LVI, lymphovascular invasion; ALND, axillary lymph node dissection; TNBC, triple-negative breast cancer; ER, estrogen receptor; PR, progesterone receptor; HER2, human epithelial growth factor receptor-2; PMRT, post-mastectomy radiotherapy.

Cumulative Survival of BCSS

Five-year BCSS was 97.9% in the non-PMRT group and 96.3% in the PMRT cohort. The BCSS curves for the PMRT and non-PMRT cohorts overlapped with each other, with no differences observed (P=0.92).

Discussion

The application of PMRT in patients with pT3N0M0 breast cancer remains controversial. Floyd et al11 assessed the value of PMRT in patients with node-negative breast tumors of 5 cm or larger. They found a low 5-year LRR rate of 7.6% (95% confidence interval, 3–16%) and 5-year DFS of 86% in the cohort and demonstrated LVI as a risk factor for worse LRFS, DFS, and OS. Taghian et al12 reviewed patients with tumors larger than 5 cm who were treated in five NSABP node-negative trials, and identified locoregional recurrence in 7.2% of patients with tumors of more than 5 cm. In our study, the 5-year LRR rate was only 1.9% and 5-year DFS was 90.5% in the non-PMRT group, better than the findings in prior studies. Moreover, the risk of LRR at 5 years in patients treated with PMRT was even lower at 0%. We noticed that the two abovementioned studies included patients between 1981 and 2002 while ours included patients between 2000 and 2016 when more advanced adjuvant chemotherapies were applied, it is likely that the improvements in systematic treatment and radiation techniques could have contributed to the lower rate of LRR and better DFS in our study.

Jagsi et al13 analyzed the local recurrence in 877 node-negative patients treated by mastectomy without PMRT. They found the chest wall was the most common site of failure, and tumor size greater than 2 cm, margin less than 2 mm, premenopausal status, and LVI were significant prognostic factors. In 2019, an analysis of the survival of 14464 female patients with TNBC diagnosed with pT1-4N0M0 from the NCDB (2004–2014) was reported, they found PMRT was associated with better OS for TNBC patients with pT3 disease.8 We only included patients with tumors of more than 5 cm, consistent with the results of Floyd et al and Jagsi et al, LVI was also identified as an unfavorable factor, and, with more specific information, we also identified TNBC and a family history of malignant tumors as unfavorable prognostic factors. Two of three patients who had all the three risk factors (TNBC subtype, grade 3, LVI +) developed LRR in our study. Taken together, we agree with the conclusions of Jagsi et al that node-negative patients with high-risk factors should be recommended PMRT to improve locoregional control.

In 2017, a retrospective, multi-institutional review regarding PMRT for pT3N0M0 patients was reported with a median follow-up of 6.2 years and 5.3 years in the non-PMRT and PMRT cohorts, respectively.14 In this study, there was an isolated local regional recurrence rate of 12% at 10 years without PMRT, and 5- and 10-year LRFS for the PMRT and non-PMRT cohorts were 98% and 88%, respectively (P=0.15).14 Consistent with their outcome, PMRT was also found to be associated with better locoregional control, but without statistical significance in our study (P=0.17), which might be attributed to the number of patients, and, more importantly, the number of events were relatively small in our study. In a study by Goulart et al15 that included 100 patients with pT2=5.0 cm and pT3 >5.0 cm tumors treated by mastectomy, a low LRR rate (2.3% in the PMRT group vs 8.9% in the non-PMRT group) was demonstrated, but, similar to our results, they found no significant improvement in LRFS and BCSS with PMRT, and concluded that PMRT should be considered for patients with grade 3 histologic features and patients without hormonal therapy. In our study, there was also a trend toward worse LRFS for patients with ER negativity and grade 3 histologic features. Besides, in our study, seven of 28 patients (25%) treated before 2008 received adjuvant chemotherapy, while 44 of 86 (81.9%) patients treated after 2008 received adjuvant chemotherapy. Anthracycline-based adjuvant chemotherapy was delivered to 57.1% of patients before 2008, while anthracycline- and taxane-based adjuvant chemotherapy took the dominant place (52.3%) after 2008. Moreover, the application of trastuzumab in HER2-positive patients increased from 0% before 2008 to 56.8% after 2008, and hormonal therapy in ER-/PR-positive patients increased from 50% before 2008 to 93.8% after 2008. For patients in PMRT group were mainly from 2009 to 2016, when systematic treatments were improved, this might partly explain why PMRT increased LRFS but without statistical significance.

Studies of pT3N0M0 patients in large populations at individual or multiple institutions have been lacking because of the infrequency of this clinical scenario, and thus many databases have been explored to analyze the features of this rare cohort. A study by Johnson et al6 analyzed 2525 patients treated between 2000 and 2010 from the SEER database and found a benefit for PMRT. Multivariate analysis indicated that PMRT improved OS (HR 0.63, P<0.001) and cancer-specific survival (HR 0.77, P=0.045), and concluded that PMRT should be strongly considered in T3N0M0 patients. Cassidy et al16 analyzed data from National Cancer Data Base (NCDB) including 3437 patients with pT3N0M0 breast cancer who were initially treated by mastectomy between 2003 and 2011. They concluded that PMRT was found to be associated with improved OS (86.3% vs 66.4%, P<0.01), regardless of surgical margin status, tumor size, and receipt of systemic therapy. Francis et al9 analyzed the survival of 4291 pT3N0M0 patients from the NCDB and found improved OS for patients with PMRT on multivariate analysis (HR 0.72, P<0.001) and in the propensity score matching cohort (P<0.001). However, both the SEER database and NCDB had no records of LRR or detailed information regarding chemotherapy and hormonal therapy, NCDB even had no information on the cause of death, which might indicate that death from causes other than breast cancer may have influenced the analyses of OS, as PMRT group had more younger patients in their studies. On the other hand, the large database studies cited may not be informative on the impact of RT on distant relapse or mortality without the knowledge of LRR. Another analysis of pT3N0M0 patients from the SEER database including patients less than 50 years old found no differences in BCSS and OS.7 In our study, we did not find a significant difference in BCSS between the two groups. Altogether, we found that there was a favorable survival for pT3N0M0 breast cancer patients, especially for those who received PMRT.

It is interesting that PMRT is the only independent factor favorable for DFS yet not so for other outcomes in our study. We think variable treatment methods patients may get when they developed local-regional recurrence (LRR) or distant metastasis might have contributed to the result that no difference of BCSS was seen between the two groups. Second, the follow-up time may be also not long enough to get a conclusion on BCSS. As for LRFS, there were only 2 patients developed LRR in our cohort, which may be the reason why no benefit of PMRT on LRFS was seen between the two groups. Besides, it is also possible that selection bias might have contributed to the results. Bigger sample size and longer follow-up are needed to get a solid conclusion.

Another intriguing thing is that a hypothesis has been proposed indicating that patients with breast cancer with a larger tumor size (>5 cm) may represent a rare subgroup with benign biological behaviors.17 In particular, a low LRR incidence was reported in previous studies, supporting the hypothesis indirectly. With the development of breast cancer classification by genotype and immunophenotype, the diagnosis for this rare cohort with pT3N0M0 breast cancer may be better interpreted. Patients who are at high risk may be distinguished from those who are not, thus avoiding unnecessary expenditure and toxicities from various treatments.

The main strength of our study is that it represents a relatively contemporary cohort of patients treated with updated systemic therapies. We were also able to obtain relatively specific clinical and pathologic information of patients. Conversely, one limitation is that, like all retrospective studies, it has selection bias and some missing information.

Conclusion

Altogether, the results of our present study confirmed a favorable survival for pT3N0M0 patients except for those with high-risk factors. With contemporary systemic therapies, the 5-year LRR rate was low in patients treated with (0%) or without PMRT (1.9%). Selected pT3N0M0 breast cancer patients with high-risk factors, such as TNBC subtype, grade 3 histologic features, and LVI+ may benefit from PMRT. On the other hand, limited by the sample size, patient selection bias might also be one of the interpretations for the better DFS in our study and the OS difference seen in the studies from the SEER and NCDB databases. So, studies stratified by genotype or immunotype as well as larger studies are warranted to better understand the biological characteristics and survival differences of this rare cohort. Individualization of radiation therapy may be indicated based on the different biological parameters.