OBJECTIVES: Cannabis legalization has increased its use. The incidence of acute pancreatitis (AP) and severe acute pancreatitis (SAP) has also increased. In this study, data on pancreatitis were obtained from 2 states before and after cannabis legalization and compared with 2 states without legalized cannabis. METHODS: Data were extracted from State Inpatient Databases from the states of Colorado and Washington before recreational cannabis legalization (2011) and after legalization (2015). Arizona and Florida were used as the nonlegalized cannabis states. Multivariable logistic regression models were fit for AP and SAP to determine a trend difference between legalized and nonlegalized cannabis states. RESULTS: Cannabis use, AP, and SAP increased in all states. The increase in AP and SAP was not significantly different between the states that legalized cannabis use and those that did not. Legalized cannabis states had lower charges for AP and SAP and shorter length of hospitalizations. CONCLUSIONS: The trend of AP and SAP increased during the study period, but this was not correlated to cannabis use. Cannabis users had lower hospitalization costs and hospital stay. The effects of other confounders such as cannabis dose and delivery methods, alcohol, tobacco, and others need to be studied further as use increases.
OBJECTIVES: Cannabis legalization has increased its use. The incidence of acute pancreatitis (AP) and severe acute pancreatitis (SAP) has also increased. In this study, data on pancreatitis were obtained from 2 states before and after cannabis legalization and compared with 2 states without legalized cannabis. METHODS: Data were extracted from State Inpatient Databases from the states of Colorado and Washington before recreational cannabis legalization (2011) and after legalization (2015). Arizona and Florida were used as the nonlegalized cannabis states. Multivariable logistic regression models were fit for AP and SAP to determine a trend difference between legalized and nonlegalized cannabis states. RESULTS: Cannabis use, AP, and SAP increased in all states. The increase in AP and SAP was not significantly different between the states that legalized cannabis use and those that did not. Legalized cannabis states had lower charges for AP and SAP and shorter length of hospitalizations. CONCLUSIONS: The trend of AP and SAP increased during the study period, but this was not correlated to cannabis use. Cannabis users had lower hospitalization costs and hospital stay. The effects of other confounders such as cannabis dose and delivery methods, alcohol, tobacco, and others need to be studied further as use increases.
Authors: Elaina Vivian; Leslie Cler; Darwin Conwell; Gregory A Coté; Richard Dickerman; Martin Freeman; Timothy B Gardner; Robert H Hawes; Prashant Kedia; Rajesh Krishnamoorthi; Hellen Oduor; Stephen J Pandol; Georgios I Papachristou; Andrew Ross; Amrita Sethi; Shyam Varadarajulu; Santhi Swaroop Vege; Wahid Wassef; C Mel Wilcox; David C Whitcomb; Bechien U Wu; Dhiraj Yadav; Ashton Ellison; Samar Habash; Sheila Rastegari; Rathan Reddy; Timothy Yen; Mary Rachel Brooks; Paul Tarnasky Journal: Am J Gastroenterol Date: 2019-08 Impact factor: 10.864
Authors: Christian Lehmann; Nicholas B Fisher; Barna Tugwell; Anna Szczesniak; Mel Kelly; Juan Zhou Journal: Clin Hemorheol Microcirc Date: 2016 Impact factor: 2.375
Authors: Christoph W Michalski; Tamara Laukert; Danguole Sauliunaite; Pál Pacher; Frank Bergmann; Nitin Agarwal; Yun Su; Thomas Giese; Nathalia A Giese; Sándor Bátkai; Helmut Friess; Rohini Kuner Journal: Gastroenterology Date: 2007-02-21 Impact factor: 22.682