Deena Thomas1, Shamnad Madathil1, Anu Thukral2, M Jeeva Sankar1, Parijat Chandra3, Ramesh Agarwal1, Ashok Deorari1. 1. Division of Neonatology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi. 2. Division of Neonatology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi. Correspondence to: Dr Anu Thukral, Associate Professor, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi 110029. dranuthukral@gmail.com. 3. Department of Ophthalmology, Dr. Rajendra Prasad Center for Ophthalmic Sciences, New Delhi.
Abstract
BACKGROUND: Algorithms for predicting retinopathy of prematurity (ROP) requiring treatment need to be validated in Indian settings to determine if the burden of screening can be reduced without compromising the sensitivity of existing gestation and weight-based cut offs. OBJECTIVE: To evaluate the performance of the available algorithms namely, WINROP (Weight, Insulin-like growth factor I, Neonatal ROP), CHOP-ROP (Children's Hospital of Philadelphia ROP) and ROPScore in predicting type 1 ROP and time from alarm to treatment by each algorithm. STUDY DESIGN: Ambispective observational. SETTING: Tertiary care neonatal intensive care unit in India. PARTICIPANTS: Neonates less than 32 weeks or less than 1500 g born between July, 2013 to June, 2019 (N=578), who underwent ROP screening. PRIMARY OUTCOME: Sensitivity, specificity and time from alarm to treatment by each algorithm. RESULTS: The sensitivity and specificity of WINROP was 85% and 36%, for CHOP-ROP it was 54% and 71%, and for ROPScore it was 73% and 67%, respectively in detecting type 1 ROP. A total of 50/51 (98%) of neonates with type 1 ROP underwent treatment at median gestation of 9 weeks and median time from alarm to treatment by WINROP, CHOP-ROP and ROPScore was 7, 7 and 3 weeks, respectively. CONCLUSION: WINROP, CHOP-ROP and ROPScore were not sensitive enough to replace the gestational age, weight and risk factor-based screening criteria for type 1 ROP.
BACKGROUND: Algorithms for predicting retinopathy of prematurity (ROP) requiring treatment need to be validated in Indian settings to determine if the burden of screening can be reduced without compromising the sensitivity of existing gestation and weight-based cut offs. OBJECTIVE: To evaluate the performance of the available algorithms namely, WINROP (Weight, Insulin-like growth factor I, Neonatal ROP), CHOP-ROP (Children's Hospital of Philadelphia ROP) and ROPScore in predicting type 1 ROP and time from alarm to treatment by each algorithm. STUDY DESIGN: Ambispective observational. SETTING: Tertiary care neonatal intensive care unit in India. PARTICIPANTS: Neonates less than 32 weeks or less than 1500 g born between July, 2013 to June, 2019 (N=578), who underwent ROP screening. PRIMARY OUTCOME: Sensitivity, specificity and time from alarm to treatment by each algorithm. RESULTS: The sensitivity and specificity of WINROP was 85% and 36%, for CHOP-ROP it was 54% and 71%, and for ROPScore it was 73% and 67%, respectively in detecting type 1 ROP. A total of 50/51 (98%) of neonates with type 1 ROP underwent treatment at median gestation of 9 weeks and median time from alarm to treatment by WINROP, CHOP-ROP and ROPScore was 7, 7 and 3 weeks, respectively. CONCLUSION: WINROP, CHOP-ROP and ROPScore were not sensitive enough to replace the gestational age, weight and risk factor-based screening criteria for type 1 ROP.
Authors: R J Hardy; W V Good; V Dobson; E A Palmer; B Tung; D L Phelps; M J Shapiro; W A J van Heuven Journal: Br J Ophthalmol Date: 2006-11 Impact factor: 4.638
Authors: Stefano Piermarocchi; Silvia Bini; Ferdinando Martini; Marianna Berton; Anna Lavini; Elena Gusson; Giorgio Marchini; Ezio Maria Padovani; Sara Macor; Silvia Pignatto; Paolo Lanzetta; Luigi Cattarossi; Eugenio Baraldi; Paola Lago Journal: Acta Ophthalmol Date: 2016-06-20 Impact factor: 3.761