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Literature DB >> 34016532

Preclinical models for investigating how bone marrow adipocytes influence bone and hematopoietic cellularity.

Abstract

Laboratory mice are a crucial preclinical model system for investigating bone marrow adipocyte (BMAd)-bone and BMAd-hematopoiesis interactions. In this review, we evaluate the suitability of mice to model common human diseases related to osteopenia or hematopoietic disorders, point out consistencies and discrepancies among different studies, and provide insights into model selection. Species, age, sex, skeletal site, and treatment protocol should all be considered when designing future studies.

Entities: Chemical

Keywords: bone; bone marrow adipocyte; bone marrow adipose tissue; hematopoiesis; preclinical models

Mesh：

Year: 2021 PMID： 34016532 PMCID： PMC8458229 DOI： 10.1016/j.beem.2021.101547

Source DB: PubMed Journal: Best Pract Res Clin Endocrinol Metab ISSN： 1521-690X Impact factor: 5.667

111 in total

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Authors: Gokhan Yaprak; Cengiz Gemici; Sule Temizkan; Sevim Ozdemir; Berfu Cinkit Dogan; Ozgur Ozan Seseogullari
Journal: BMC Cancer Date: 2018-10-11 Impact factor: 4.430

1 in total

1. Lipolysis of bone marrow adipocytes is required to fuel bone and the marrow niche during energy deficits.

Authors: Ziru Li; Emily Bowers; Junxiong Zhu; Hui Yu; Julie Hardij; Devika P Bagchi; Hiroyuki Mori; Kenneth T Lewis; Katrina Granger; Rebecca L Schill; Steven M Romanelli; Simin Abrishami; Kurt D Hankenson; Kanakadurga Singer; Clifford J Rosen; Ormond A MacDougald
Journal: Elife Date: 2022-06-22 Impact factor: 8.713

1 in total