Sabrina Chiapinotto1, Edgar E Sarria2, Helena T Mocelin3, João A B Lima4, Rita Mattiello5, Gilberto B Fischer6. 1. Postgraduate Program in Pulmonology, UFRGS, Porto Alegre, Brazil. 2. Pediatric Pulmonology Section, Hospital da Criança Santo Antônio, Porto Alegre, Brazil. 3. Pediatric Pulmonology Section, Hospital da Criança Santo Antônio, Porto Alegre, Brazil; Pediatrics Department, Federal University of Health Sciences of Porto Alegre, Brazil. 4. Pediatric Pulmonology Section, Hospital da Criança Santo Antônio, Porto Alegre, Brazil; Porto Alegre City Health Department, Porto Alegre, Brazil. 5. Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil. 6. Pediatric Pulmonology Section, Hospital da Criança Santo Antônio, Porto Alegre, Brazil; Pediatrics Department, Federal University of Health Sciences of Porto Alegre, Brazil; Postgraduate Program in Pediatrics, UFCSPA, Porto Alegre, Brazil. Electronic address: gilbertobf@ufcspa.edu.br.
Abstract
INTRODUCTION: Interventions to deal with the COVID-19 pandemic may impact the burden of other respiratory diseases. The aim of this study is to analyze the impact of non-pharmacological initiatives (NPI) against COVID-19 on the number of hospitalizations due to pediatric acute respiratory illnesses (ARIs). MATERIAL AND METHODS: This is a retrospective analysis of pediatric hospitalizations in Porto Alegre, Brazil. We analyzed the monthly incidence of hospital admissions from 2018 to 2020 due to ARIs included in the study. The time series was divided into the period before introducing NPI (2018 and 2019), and the period when NPI were running (2020). We compared means between the years with Student's t-test. The Dickey-Fuller test was used for secular trend analysis. For seasonality, Fischer's G test was performed. Dynamic linear univariate and multivariate models were used to estimate the association between the predictors (the introduction of NPI, secular trend, and seasonality) and outcome (the incidence of ARI admissions). For the statistical analysis, the cut-off probability for rejecting the null hypothesis was defined as <5%. RESULTS: From 2018 to 2020, 10,109 hospital admissions were due to the respiratory causes included in this study. There was a significant decrease in 2020 in the mean incidence of the ARIs studied compared with 2018 and 2019. The number of hospitalizations due to respiratory diseases in children decreased by 64% for asthma and 93% for bronchiolitis. A secular trend of monthly admissions rates due to ARIs was only observed in the laryngotracheitis data (p = 0.485), but seasonality was detected in all analyses. According to the univariate and multivariate analysis, the introduction of NPI was associated with a decrease in the incidence of ARI admissions. CONCLUSION: There was a significant reduction in hospital admissions due to ARIs in children. Our data suggest a significant impact of NPI on reducing the spread of viruses associated with ARIs in children. These results support respiratory illness prevention strategies.
INTRODUCTION: Interventions to deal with the COVID-19 pandemic may impact the burden of other respiratory diseases. The aim of this study is to analyze the impact of non-pharmacological initiatives (NPI) against COVID-19 on the number of hospitalizations due to pediatric acute respiratory illnesses (ARIs). MATERIAL AND METHODS: This is a retrospective analysis of pediatric hospitalizations in Porto Alegre, Brazil. We analyzed the monthly incidence of hospital admissions from 2018 to 2020 due to ARIs included in the study. The time series was divided into the period before introducing NPI (2018 and 2019), and the period when NPI were running (2020). We compared means between the years with Student's t-test. The Dickey-Fuller test was used for secular trend analysis. For seasonality, Fischer's G test was performed. Dynamic linear univariate and multivariate models were used to estimate the association between the predictors (the introduction of NPI, secular trend, and seasonality) and outcome (the incidence of ARI admissions). For the statistical analysis, the cut-off probability for rejecting the null hypothesis was defined as <5%. RESULTS: From 2018 to 2020, 10,109 hospital admissions were due to the respiratory causes included in this study. There was a significant decrease in 2020 in the mean incidence of the ARIs studied compared with 2018 and 2019. The number of hospitalizations due to respiratory diseases in children decreased by 64% for asthma and 93% for bronchiolitis. A secular trend of monthly admissions rates due to ARIs was only observed in the laryngotracheitis data (p = 0.485), but seasonality was detected in all analyses. According to the univariate and multivariate analysis, the introduction of NPI was associated with a decrease in the incidence of ARI admissions. CONCLUSION: There was a significant reduction in hospital admissions due to ARIs in children. Our data suggest a significant impact of NPI on reducing the spread of viruses associated with ARIs in children. These results support respiratory illness prevention strategies.
Authors: Frederico Friedrich; Lucas Montiel Petry; Marcos Brum; Pedro Augusto Van Der Sand Germani; Bruno Brocker Nunes; Giovani Zocche; Martina Lopez Torres; Eduarda Tassoni Kafer; Alice Corso Enet; Carolina Fontana Irschlinger; Laura Provenzi; Marcelo C Scotta; Renato T Stein; Marcus Herbert Jones; Paulo Márcio Pitrez; Leonardo Araújo Pinto Journal: J Allergy Clin Immunol Glob Date: 2022-04-30
Authors: Carolina F Dias; Edgar E Sarria; Camila Scheffel; Laura B Delatorre; Alexander Sapiro; Marilisa Baldissera; Sabrina Chiapinotto; Helena T Mocelin; Gilberto B Fischer; Rita Mattiello Journal: Arch Bronconeumol Date: 2021-10-01 Impact factor: 6.333
Authors: Fernando de Sá Del Fiol; Cristiane de Cássia Bergamaschi; Isaltino Pereira De Andrade; Luciane Cruz Lopes; Marcus Tolentino Silva; Silvio Barberato-Filho Journal: Front Pharmacol Date: 2022-03-21 Impact factor: 5.810