| Literature DB >> 34016449 |
Eunah Kim1, Yoon Ki Kim2, Seung-Jae V Lee3.
Abstract
Circular RNA (circRNA) is a closed, single-stranded transcript widely detected in eukaryotes. Recent studies indicate that the levels of circRNAs change with age in various tissues in multiple species, ranging from nematodes to mammals. Here we discuss the functional roles of circRNAs in animal aging and longevity. We review studies regarding the differential expression of circRNAs that contributes to cellular senescence and the pathogenesis of aging-associated diseases. We explore the features of aging-associated circRNAs by discussing their potential as biomarkers of aging, tissue specificity, physiological roles, action mechanisms, and evolutionarily conserved characteristics. Our review provides insights into current progress in circRNA research and their significant functions in the aging process.Keywords: age-associated disease; aging; biomarker of aging; circular RNAs; senescence
Year: 2021 PMID： 34016449 DOI： 10.1016/j.tig.2021.04.014
Source DB: PubMed Journal: Trends Genet ISSN： 0168-9525 Impact factor: 11.639