C van Marcke1,2, N Honoré1,2, A van der Elst1,2, S Beyaert2, F Derouane1,2, C Dumont1, F Aboubakar Nana3,4, J F Baurain1,2, I Borbath1,2,5, P Collard3,4, F Cornélis1,2, A De Cuyper1,2, F P Duhoux1,2, B Filleul1,6, R Galot1,2, M Gizzi1,7, F Mazzeo1,2, T Pieters3,4, E Seront1,6, I Sinapi1,7, M Van den Eynde1,2,5, N Whenham1,8, J C Yombi2,9, A Scohy10, A van Maanen11, J P Machiels12,13. 1. Department of Medical Oncology, Institut Roi Albert II, Cliniques universitaires Saint-Luc, Avenue Hippocrate 10, 1200, Brussels, Belgium. 2. Institute for Experimental and Clinical Research (IREC, pôle MIRO), Université catholique de Louvain (UCLouvain), Avenue Hippocrate 10, 1200, Brussels, Belgium. 3. Department of Pneumology, Institut Roi Albert II, Cliniques universitaires Saint-Luc, Brussels, Belgium. 4. Institute for Experimental and Clinical Research (IREC, pôle PNEU), Université catholique de Louvain (UCLouvain), Brussels, Belgium. 5. Department of Hepatogastroenterology, Institut Roi Albert II, Cliniques universitaires Saint-Luc, Brussels, Belgium. 6. Department of Medical Oncology, Hôpital de Jolimont, Haine-Saint-Paul, Belgium. 7. Department of Medical Oncology, Grand Hôpital de Charleroi (GHdC), Charleroi, Belgium. 8. Department of Medical Oncology, Clinique Saint-Pierre, Ottignies, Belgium. 9. Department of General Internal Medicine, Cliniques universitaires Saint-Luc, Brussels, Belgium. 10. Department of Microbiology, Cliniques universitaires Saint-Luc, Brussels, Belgium. 11. Statistics unit, Institut Roi Albert II, Cliniques universitaires Saint-Luc, Brussels, Belgium. 12. Department of Medical Oncology, Institut Roi Albert II, Cliniques universitaires Saint-Luc, Avenue Hippocrate 10, 1200, Brussels, Belgium. jean-pascal.machiels@uclouvain.be. 13. Institute for Experimental and Clinical Research (IREC, pôle MIRO), Université catholique de Louvain (UCLouvain), Avenue Hippocrate 10, 1200, Brussels, Belgium. jean-pascal.machiels@uclouvain.be.
Abstract
BACKGROUND: The viral pandemic coronavirus disease 2019 (COVID-19) has disrupted cancer patient management around the world. Most reported data relate to incidence, risk factors, and outcome of severe COVID-19. The safety of systemic anti-cancer therapy in oncology patients with non-severe COVID-19 is an important matter in daily practice. METHODS: ONCOSARS-1 was a single-center, academic observational study. Adult patients with solid tumors treated in the oncology day unit with systemic anti-cancer therapy during the initial phase of the COVID-19 pandemic in Belgium were prospectively included. All patients (n = 363) underwent severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) serological testing after the first peak of the pandemic in Belgium. Additionally, 141 of these patients also had a SARS-CoV-2 RT-PCR test during the pandemic. The main objective was to retrospectively determine the safety of systemic cancer treatment, measured by the rate of adverse events according to the Common Terminology Criteria for Adverse Events, in SARS-CoV-2-positive patients compared with SARS-CoV-2-negative patients. RESULTS: Twenty-two (6%) of the 363 eligible patients were positive for SARS-CoV-2 by RT-PCR and/or serology. Of these, three required transient oxygen supplementation, but none required admission to the intensive care unit. Hematotoxicity was the only adverse event more frequently observed in SARS-CoV-2 -positive patients than in SARS-CoV-2-negative patients: 73% vs 35% (P < 0.001). This association remained significant (odds ratio (OR) 4.1, P = 0.009) even after adjusting for performance status and type of systemic treatment. Hematological adverse events led to more treatment delays for the SARS-CoV-2-positive group: 55% vs 20% (P < 0.001). Median duration of treatment interruption was similar between the two groups: 14 and 11 days, respectively. Febrile neutropenia, infections unrelated to COVID-19, and bleeding events occurred at a low rate in the SARS-CoV-2-positive patients. CONCLUSION: Systemic anti-cancer therapy appeared safe in ambulatory oncology patients treated during the COVID-19 pandemic. There were, however, more treatment delays in the SARS-CoV-2-positive population, mainly due to a higher rate of hematological adverse events.
BACKGROUND: The viral pandemic coronavirus disease 2019 (COVID-19) has disrupted cancerpatient management around the world. Most reported data relate to incidence, risk factors, and outcome of severe COVID-19. The safety of systemic anti-cancer therapy in oncology patients with non-severe COVID-19 is an important matter in daily practice. METHODS: ONCOSARS-1 was a single-center, academic observational study. Adult patients with solid tumors treated in the oncology day unit with systemic anti-cancer therapy during the initial phase of the COVID-19 pandemic in Belgium were prospectively included. All patients (n = 363) underwent severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) serological testing after the first peak of the pandemic in Belgium. Additionally, 141 of these patients also had a SARS-CoV-2 RT-PCR test during the pandemic. The main objective was to retrospectively determine the safety of systemic cancer treatment, measured by the rate of adverse events according to the Common Terminology Criteria for Adverse Events, in SARS-CoV-2-positive patients compared with SARS-CoV-2-negative patients. RESULTS: Twenty-two (6%) of the 363 eligible patients were positive for SARS-CoV-2 by RT-PCR and/or serology. Of these, three required transient oxygen supplementation, but none required admission to the intensive care unit. Hematotoxicity was the only adverse event more frequently observed in SARS-CoV-2 -positive patients than in SARS-CoV-2-negative patients: 73% vs 35% (P < 0.001). This association remained significant (odds ratio (OR) 4.1, P = 0.009) even after adjusting for performance status and type of systemic treatment. Hematological adverse events led to more treatment delays for the SARS-CoV-2-positive group: 55% vs 20% (P < 0.001). Median duration of treatment interruption was similar between the two groups: 14 and 11 days, respectively. Febrile neutropenia, infections unrelated to COVID-19, and bleeding events occurred at a low rate in the SARS-CoV-2-positive patients. CONCLUSION: Systemic anti-cancer therapy appeared safe in ambulatory oncology patients treated during the COVID-19 pandemic. There were, however, more treatment delays in the SARS-CoV-2-positive population, mainly due to a higher rate of hematological adverse events.
Authors: Scott Simpson; Fernando U Kay; Suhny Abbara; Sanjeev Bhalla; Jonathan H Chung; Michael Chung; Travis S Henry; Jeffrey P Kanne; Seth Kligerman; Jane P Ko; Harold Litt Journal: J Thorac Imaging Date: 2020-07 Impact factor: 3.000
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Authors: G Curigliano; S Banerjee; A Cervantes; M C Garassino; P Garrido; N Girard; J Haanen; K Jordan; F Lordick; J P Machiels; O Michielin; S Peters; J Tabernero; J Y Douillard; G Pentheroudakis Journal: Ann Oncol Date: 2020-07-31 Impact factor: 32.976
Authors: Tigist W Leulseged; Kindalem G Abebe; Ishmael S Hassen; Endalkachew H Maru; Wuletaw C Zewde; Negat W Chamiso; Kalkidan T Yegele; Abdi B Bayisa; Dagne F Siyoum; Mesay G Edo; Edmialem G Mesfin; Meskerem N Derejie; Helina K Shiferaw Journal: PLoS One Date: 2022-01-27 Impact factor: 3.240